Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2

Table 1 Morphometric, hemodynamic and echocardiographic characteristics of cardiac function 150 days after ACF.

	Sham	ACF
*Morphometry*
Body weight, g	592 ± 20.9	586 ± 23.4
Heart weight/BW, g/100 g	2.80 ± 0.12	5.29 ± 0.18 *
Lung Weight/BW, g/100 g	3.30 ± 0.16	4.23 ± 0.19 *
*Hemodynamics*
Heart rate, s^-1	344.9 ± 13.3	360.1 ± 10.8
Peak LV pressure, mmHg	129 ± 7.11	120 ± 3.96
End-diastolic LV pressure, mmHg	6.7 ± 0.84	12.1 ± 0.66 *
*Echocardiography*
LV diastolic diameter, mm	6.08 ± 0.40	10.20 ± 0.48 *
LV systolic diameter, mm	1.95 ± 0.42	5.47 ± 0.42 *
LV Fractional shortening, %	69.2 ± 5.00	46.7 ± 2.46 *
LV anterior wall diastolic thickness, mm	2.30 ± 0.08	2.33 ± 0.09
LV posterior wall diastolic thickness, mm	2.33 ± 0.07	2.31 ± 0.09
RV diastolic diameter, mm	2.85 ± 0.18	5.07 ± 0.29 *

n = 10/group. Data are mean ± SE.
BW: Body weight, ACF: aorto-caval fistula group, LV: left ventricle, RV: right ventricle.
* significantly different (p < 0.05) than sham-operated animals.

ISSN: 1477-5956