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Table 2 Comparison between ATPsite, ATPint and three baseline predictors that use alignment (BLAST), conservation scoring (rate4site) and evolutionary profiles (PSSM+SVM). The “Significance” column reports statistical significance tests that compare paired per-sequence AUC and MCC between ATPsite and other methods; + indicates that ATPsite is significantly better at 0.01 level.

From: ATPsite: sequence-based prediction of ATP-binding residues

Predictor Predicted probabilities Predicted binary annotations
  AUC Significance SENS SPEC ACC MCC Significance
ATPsite 0.854   0.361 0.988 0.962 0.433  
Rate4site 0.749 + 0.446 0.87 0.852 0.182 +
PSSM+SVM 0.824 + 0.354 0.957 0.933 0.27 +
BLAST Not applicable 0.243 0.993 0.962 0.359 +
ATPint 0.627 + 0.539 0.651 0.648 0.078 +