Table 2 Comparison between ATPsite, ATPint and three baseline predictors that use alignment (BLAST), conservation scoring (rate4site) and evolutionary profiles (PSSM+SVM). The “Significance” column reports statistical significance tests that compare paired per-sequence AUC and MCC between ATPsite and other methods; + indicates that ATPsite is significantly better at 0.01 level.
From: ATPsite: sequence-based prediction of ATP-binding residues
Predictor | Predicted probabilities | Predicted binary annotations | |||||
|---|---|---|---|---|---|---|---|
AUC | Significance | SENS | SPEC | ACC | MCC | Significance | |
ATPsite | 0.854 | 0.361 | 0.988 | 0.962 | 0.433 | ||
Rate4site | 0.749 | + | 0.446 | 0.87 | 0.852 | 0.182 | + |
PSSM+SVM | 0.824 | + | 0.354 | 0.957 | 0.933 | 0.27 | + |
BLAST | Not applicable | 0.243 | 0.993 | 0.962 | 0.359 | + | |
ATPint | 0.627 | + | 0.539 | 0.651 | 0.648 | 0.078 | + |