Figure 1
From: Prediction of 492 human protein kinase substrate specificities
Kinase catalytic domain alignment. Some of the well characterized protein kinases with critical amino acids in their catalytic domains. In the right most column, (–3) position of the consensus sequence of each kinase is shown. Strongly positively charged amino acids (R, K) are represented as blue, weakly positively charged histidine as light blue, strongly negatively charged amino acids (E, D) as red, hydrophobic amino acids (L, V, I, F) as green, and proline (P) as brown.