Proteomic study of sporadic inclusion body myositis

Li, Ke; Pu, Chuanqiang; Huang, Xusheng; Liu, Jiexiao; Mao, Yanling; Lu, Xianghui

doi:10.1186/s12953-014-0045-2

Proteome Science

Table 2 Search results of proteins with differential expression using Mascot database

From: Proteomic study of sporadic inclusion body myositis

Spot No.	Protein name	Score*	Chromosome	NCBI index	Expression	Function
1	Aldehyde dehydrogenase 1 family, member A1	141	9q21.13	gi\|21361176	↑	Oxidation reduction
2	Enolase 1, (alpha)	218	1p36.3-p36.2	gi\|4503571	↑	Negative regulation of cell growth
3	Amyloid beta A4 protein precursor	80	21q21.2;21q21.3	gi\|4502167	↑	Neuron apoptosis, ion binding
4	Troponin T type 1 (skeletal, slow)	165	19q13.4	gi\|187173290	↑	Troponin T binding, muscle contraction
5	Voltage-dependent anion channel 2	130	10q22	gi\|55664661	↑	Ion channel activity
6	Myosin, light chain 6B, alkali, smooth muscle and non-muscle	230	12q13.13	gi\|4505303	↑	Muscle contraction
7	Superoxide dismutase 2, mitochondrial	127	6q25.3	gi\|67782305	↑	Antioxidant activity
8	Peroxiredoxin 1	230	1p34.1	gi\|4505591	↑	Oxidoreductase activity
9	Crystallin, alpha B	172	11q22.3-q23.1	gi\|4503057	↑	Response to reactive oxygen species
10	Heat shock protein, alpha-crystallin-related, B6	70	19q13.12	gi\|21389433	↑	Response to temperature stimulus
11	Myosin, light chain 2, regulatory, cardiac, slow	248	12q24.11	gi\|94981553	↑	Regulation of muscle contraction
12	Cytochrome c oxidase subunit Va	61	15q24.1	gi\|190885499	↓	Oxidation reduction
13	S100 calcium binding protein A13	76	1q21	gi\|62632859	↑	Calcium ion binding
14	Fatty acid binding protein 3	147	1p33-p32	gi\|4758328	↑	Lipid transporter activity
15	Transgelin	164	11q23.2	gi\|48255905	↑	Actin binding
16	Fibrinogen beta chain	280	4q28	gi\|70906435	↓	Cell activation, protein complex assembly
17	Myosin heavy chain IIa	125	17p13.1	gi\|153791586	↓	Muscle contraction
18	Enolase 3 (beta, muscle)	72	17pter-p11	gi\|119610782	↓	Phosphopyruvate hydratase activity, skeletal muscle regeneration
19	Troponin T3, skeletal, fast isoform 2	111	11p15.5	gi\|112789538	↓	Muscle contraction
20	Carbonic anhydrase I	80	8q13-q22.1	gi\|4502517	↓	Carbonate dehydratase activity, ion binding
21	Uridine monophosphate synthetase	68	3q13	gi\|197210454	↓	Pyrimidine nucleoside metabolic process
22	Adaptor-related protein complex 3, mu 2 subunit	127	8p11.2	gi\|5803000	↓	Protein transport
23	Haptoglobin-related protein	60	16q22.1	gi\|296653	↓	Proteolysis
24	Hemoglobin beta	106	11p15.5	gi\|75491671	↓	Oxygen transporter activity
25	Albumin	141	4q11-q13	gi\|27692693	↓	Response to starvation, antioxidant activity
26	Myosin, heavy chain 7, cardiac muscle, beta	122	14q12	gi\|386973	↓	Muscle contraction
27	Troponin I type 1 (skeletal, slow)	162	1q31.3	gi\|14787427	↓	Regulation of muscle contraction
28	Chain A, Human peroxiredoxin 5	114	11q13	gi\|6912238	↑	Oxidoreductase activity
29	Rho GDP dissociation inhibitor (GDI) alpha	83	17q25.3	gi\|4757768	↑	Small GTPase regulator activity

*Mascot score (Mascot score > 65; P < 0.05, the P-value has been generated by the DAVID algorithm and were adjusted for multiple comparisons).

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