Proteomic study of sporadic inclusion body myositis

Table 3 Major functions of proteins with differential expression

Function annotation	Gene number	Spot No.	P-value
Biology process
Muscle contraction	9	9, 17, 26, 6, 4, 19, 10, 27, 11	1.1E-5
Cytoskeleton	10	29, 3, 9, 17, 26, 11, 6, 4, 19, 27	3.9E-4
Regulation of apoptosis	7	29, 25, 3, 9, 8, 28, 7	4.4E-3
Negative regulation of apoptosis	5	29, 25, 9, 28, 7	5.0E-3
Response to reactive oxygen species	5	9, 26, 8, 28, 7	1.4E-5
Regulation of muscle contraction	5	11, 27, 4, 19, 10	3.9E-4
Cellular homeostasis	5	3, 23, 8, 28, 7	1.3E-2
Cytoskeleton-dependent intracellular transport	4	3, 17, 26, 6	1.5E-4
Stress-activated MAPK cascade	2	9, 8	2E-4
Molecular function
Cytoskeletal protein binding	8	9, 17, 26, 11, 15, 27, 4, 19	4.4E-5
Pyrophosphatase activity	5	17, 11, 6, 26, 19	2.0E-2
Oxidoreductase	5	1, 12, 8, 28, 7	8.5E-3
Antioxidant activity	4	25, 8, 28, 7	1.1E-4
Glucose metabolic process	3	9, 2, 18	3.7E-2
Phosphopyruvate hydratase activity	2	18, 2	1.0E-2
Focal adhesion	2	17, 26	1.2E-2

Table 3 represent a list of KEGG associated to single protein changed in sIBM, related enriched protein are reported in Table 2, but are not consistent. For example, for proteins 11, 12, 26 associated to muscle contraction signal pathway, 11 and 26 are also reported in Table 2 (proteins associated to biological function of muscle contraction). For 11, 17, 26 associated to Tight junction signal pathway, 17 and 26 are also reported in Table 2 (proteins associated to biological function of focal adhesion).

ISSN: 1477-5956