Table 1 Summary of differentially expressed proteins

1

P08107

Heat shock 70 kDa protein 1A/1B

Unfolded protein binding

PMF, MS/MS

8

5.47/70.05

98

2.03 (2.55)*

2

P17987

T-complex protein 1 subunit alpha

Molecular chaperonin

MS/MS

17

5.80/60.34

103

3.91

3

P50453

Serpin B9

Cysteine-type endopeptidase inhibitor activity involved in apoptotic process

PMF, MS/MS

4

5.61/42.40

67

2.34

4

P08670

Vimentin

Double-stranded RNA binding

PMF

5.05/53.65

122

4.84

5

P04083

Annexin A1

Calcium ion binding

PMF

5.85/38.71

132

2.94

6

P20839

Inosine-5′-monophosphate dehydrogenase 1

IMP dehydrogenase activity, metal ion binding

PMF, MS/MS

5

6.43/55.41

116

2.17

7

P12532

Creatine kinase U-type

ATP binding

PMF, MS/MS

3

7.31/43.08

89

3.15

8

P04075

Fructose-bisphosphate aldolase A

Fructose-bisphosphate aldolase activity

PMF

8.30/39.42

142

4.14

9

P52565

Rho GDP-dissociation inhibitor 1

GTPase activator activity

PMF, MS/MS

5

5.01/23.21

127

3.06

10

P07195

L-lactate dehydrogenase B chain

L-lactate dehydrogenase activity

PMF

5.71/36.64

84

2.58

11

V9HW96

Chaperonin containing TCP1, subunit 2 (Beta), isoform CRA_b

Molecular chaperonin

PMF

6.01/57.49

133

2.09

12

P30041

Peroxiredoxin-6

Antioxidant activity

PMF, MS/MS

8

6.00/25.03

93

3.56

13

O00299

Chloride intracellular channel protein 1

Chloride channel activity

PMF, MS/MS

9

5.09/26.92

122

4.19

14

P30626

Sorcin

Calcium channel regulator activity

PMF, MS/MS

4

5.32/21.68

142

50.70

15

P31949

Protein S100-A11

Calcium ion binding

PMF, MS/MS

3

6.65/11.74

89

2.92

16

P00558

Phosphoglycerate kinase 1

Phosphoglycerate kinase activity

PMF

8.30/44.61

91

3.13

17

P06733

Alpha-enolase

Phosphopyruvate hydratase activity

PMF, MS/MS

22

7.01/47.17

123

2.17 (2.93)*

18

Q9NR45

Sialic acid synthase

N-acetylneuraminate synthase activity

PMF

6.29/40.31

97

2.04

19

P62837

Ubiquitin-conjugating enzyme E2 D2

Ubiquitin-protein ligase activity

PMF, MS/MS

4

7.69/16.74

137

2.46

20

P05787

Keratin, type II cytoskeletal 8

Scaffold protein binding

PMF, MS/MS

9

5.52/53.71

152

2.03

21

Q14320

Protein FAM50A

Poly(A) RNA binding

PMF, MS/MS

6

6.39/40.24

104

2.38

22

P09972

Fructose-bisphosphate aldolase C

Fructose-bisphosphate aldolase activity

PMF

6.41/39.46

79

2.11

23

Q08752

Peptidyl-prolyl cis-trans isomerase D

Hsp70 protein binding

PMF, MS/MS

3

6.77/40.76

83

3.17

24

P16422

Epithelial cell adhesion molecule

Protein complex binding

PMF

7.42/34.93

131

2.51

25

P37837

Transaldolase

Monosaccharide binding

PMF, MS/MS

4

6.36/37.54

89

2.04

26

P11926

Ornithine decarboxylase

Ornithine decarboxylase activity

PMF

5.10/51.15

79

3.23

27

P09525

Annexin A4

Calcium ion binding

PMF, MS/MS

2

5.83/35.88

169

4.24

28

P06744

Glucose-6-phosphate isomerase

Glucose-6-phosphate isomerase activity

PMF, MS/MS

4

8.42/63.15

213

3.78

29

P27797

Calreticulin

Calcium ion binding

PMF, MS/MS

4

4.29/48.14

228

2.22

30

P05783

Keratin, type I cytoskeletal 18

Scaffold protein binding

PMF, MS/MS

11

5.34/48.06

142

2.13

31

P30101

Protein disulfide-isomerase A3

Cysteine-type endopeptidase activity

PMF, MS/MS

7

5.98/56.78

103

0.32

32

P28070

Proteasome subunit beta type-4

Threonine-type endopeptidase activity

PMF, MS/MS

2

5.70/29.20

187

0.23

33

Q99LB4

Capping protein (Actin filament), gelsolin-like

Cell projection assembly

PMF

6.47/38.77

109

0.29

34

Q9NNW7

Thioredoxin reductase 2, mitochondrial

Thioredoxin-disulfide reductase activity

PMF

7.24/56.51

93

0.43

35

O95782

AP-2 complex subunit alpha-1

Protein transporter activity

PMF, MS/MS

7

6.63/107.5

167

0.41

36

Q16082

Heat shock protein beta-2

Enzyme activator activity

PMF

5.07/20.23

102

0.38 (0.52)*

37

P42330

Aldo-keto reductase family 1 member C3

Androsterone dehydrogenase activity

PMF

8.06/36.85

146

0.45

38

Q16553

Lymphocyte antigen 6E

Epinephrine secretion

PMF

8.06/13.51

129

0.48

39

P35232

Prohibitin

Sequence-specific DNA binding RNA polymerase II transcription factor activity

PMF, MS/MS

2

5.57/29.80

114

0.28

40

Q92729

Receptor-type tyrosine-protein phosphatase U

Beta-catenin binding

PMF

6.46/16.24

92

0.21

41

P02649

apolipoprotein E

Antioxidant activity

PMF

5.65/36.15

83

0.31

42

Q15181

Inorganic pyrophosphatase

Inorganic diphosphatase activity

PMF, MS/MS

4

5.54/32.66

162

0.25

43

P06576

ATP synthase subunit beta, mitochondrial

Proton-transporting ATP synthase activity, rotational mechanism

PMF, MS/MS

7

5.26/56.56

127

0.41

44

P52597

Heterogeneous nuclear ribonucleoprotein F

RNA binding

PMF, MS/MS

3

5.37/45.67

215

0.46