Figure 3

Pathways and networks associated with proteins with differential abundance according to IPA. (A) The top canonical pathway significantly associated with the differentially expressed proteins - Acute Phase Response Signaling (p = 6,99 e⁻¹⁴). (B) Highest ranked protein network of functional associations between 23 proteins with differential abundance - Cancer, Organism injury and abnormalities and Gastrointestinal Disease. Most of the proteins with differential abundance are closely connected in the network through three major nodes: P38 MARK, Pro-inflamatory cytokine and ERK1/2. The network is graphically displayed with proteins as nodes and the biological relationships between the nodes as lines. The color of the shapes indicates the degree of over-expression (red) or under-expression (green) of the corresponding protein in PCa compared to BPH samples. Direct connection between molecules is represented by a solid line and indirect connection by broken line. The length of a line reflects published evidence supporting the node-to-node relationship concerned. (C) Selected subset of proteins with differential abundance associated with cancer in humans or cancer cell lines.