Table 1 List of proteins with differential abundance identified by MALDI-MS

1

0.010

−2.53

Serotransferrin

TRFE_HUMAN

79.29

6.81

98

80

3.1E-06

10/15

21

2

0.010

−2.64

Serotransferrin

TRFE_HUMAN

79.29

6.81

200

47

2.0E-16

23/43

38

3

0.010

−2.64

Serotransferrin

TRFE_HUMAN

79.29

6.81

243

57

1.0E-20

22/30

40

4

0.033

−2.17

Alpha-1-antitrypsin

A1AT_HUMAN

46.89

5.37

81

56

1.9E-04

12/31

31

5

0.002

−5.21

Alpha-1-antitrypsin

A1AT_HUMAN

46.89

5.37

128

82

3.2E-09

18/34

36

6

0.002

−4.34

Alpha-1-antitrypsin

A1AT_HUMAN

46.89

5.37

194

51

8.1E-16

23/43

53

7

0.002

−3.66

Alpha-1-antitrypsin

A1AT_HUMAN

46.89

5.37

74

109

7.7E-04

12/28

27

8

0.001

−3.05

Alpha-1-antitrypsin

A1AT_HUMAN

46.89

5.37

178

63

3.2E-14

20/31

41

9

0.000

−4.27

Alpha-1-antitrypsin

A1AT_HUMAN

46.89

5.37

66

102

4.9E-03

9/17

26

10

0.010

−3.18

Vitamin D-binding protein

VTDB_HUMAN

54.52

5.40

135

65

6.4E-10

12/24

50

11

0.011

−6.11

Fibrinogen gamma chain

FIBG_HUMAN

52.10

5.37

164

108

8.1E-13

17/30

47

12

0.019

−4.41

Thymidine phosphorylase

TYPH_HUMAN

50.32

5.36

64

104

7.4E-03

5/13

25

13

0.036

2.59

Gelsolin

GELS_HUMAN

86.04 (52.48)

5.90 (5.34)

80

81

2.0E-03

9/15

16

14

0.004

4.75

Fibrinogen alpha chain (fragment)

FIBA_HUMAN

95.65 (~50)

5.70 (4.65)

91

99

1.6E-05

10/18

15

15

0.003

2.47

Endonuclease domain-containing 1 protein

ENDD1_HUMAN

55.72

5.55

104

122

8.1E-07

9/13

20

16

0.000

3.07

E3 ubiquitin-protein ligase rififylin

RFFL_HUMAN

41.74

5.33

59

97

2.7E-02

5/12

26

17

0.009

2.72

Inter-alpha-trypsin inhibitor heavy chain H4 (fragment)

ITIH4_HUMAN

103,52 (~45)

6,51 (5,00)

64

51

9.1E-03

13/26

12

18

0.004

2.66

Inter-alpha-trypsin inhibitor heavy chain H4 (fragment)

ITIH4_HUMAN

103.52 (~45)

6.51 (5.15)

88

134

2.9E-05

11/26

13

19

0.001

4.75

Quinone oxidoreductase-like protein 1

QORL1_HUMAN

39.07

5.49

66

91

4.9E-02

4/12

12

20

0.005

3.17

Interleukin enhancer-binding factor 2

ILF2_HUMAN

43.26

5.19

62

82

3.0E-02

5/13

19

21

0.002

5.07

Vesicular integral-membrane protein VIP36

LMAN2_HUMAN

40.54

6.46

80

75

1.9E-04

7/14

21

22

0.041

2.26

Protein AMBP

AMBP_HUMAN

39.87

5.95

86

15

5.5E-05

8/15

22

23

0.048

2.25

Protein AMBP

AMBP_HUMAN

39.87

5.95

93

78

9.9E-06

10/24

23

24

0.044

2.26

Protein AMBP

AMBP_HUMAN

39.87

5.95

94

109

8.4E-06

10/19

24

25

0.035

2.35

Protein AMBP

AMBP_HUMAN

39.87

5.95

130

93

2.0E-09

15/35

37

26

0.023

3.33

Prostaglandin-H2 D-isomerase

PTGDS_HUMAN

21.24

7.66

61

52

1.8E-02

7/17

32

27

0.033

3.43

Prostaglandin-H2 D-isomerase

PTGDS_HUMAN

21.24

7.66

64

23

7.7E-03

8/36

33

28

0.005

−3.25

Apolipoprotein A-I

APOA1_HUMAN

30.75

5.56

116

57

5.1E-08

16/53

46

29

0.010

−6.82

Apolipoprotein A-I

APOA1_HUMAN

30.75

5.56

171

74

1.6E-13

20/55

57

30

0.009

3.55

Basement membrane specific heparan sulphate proteoglycan core protein (PERLECAN) (fragment)

PGBM_HUMAN

468.83 (20.65)

6.06 (5.47)

204

62

1.1E-15

15/33

88

31

0.001

4.60

CD59 glycoprotein

CD59_HUMAN

14.79

6.02

58

103

2.9E-02

4/7

21

32

0.006

3.11

CD59 glycoprotein

CD59_HUMAN

14.79

6.02

58

32

2.9E-02

4/7

21

33

0.000

4.17

CD59 glycoprotein

CD59_HUMAN

14.79

6.02

61

47

1.6E-02

5/15

28

34

0.001

6.56

Secreted and transmembrane protein 1

SCTM1_HUMAN

27.30

7.00

66

34

4.9E-03

6/13

22

35

0.019

−5.51

Haptoglobin (fragment, alpha 2 chain)

HPT_HUMAN

45.86 (~16)

6.13 (6.20)

73

79

9.3E-03

4/11

28

36

0.017

2.26

Mannan-binding lectin serine protease 2 (chainA, Human MBL associated protein 19)

MASP2_HUMAN

77.19 (19.53)

5.39 (5.44)

127

24

5.5E-08

7/14 (8/14)

37

37

0.015

−5.86

Haptoglobin (fragment, alpha 2 chain)

HPT_HUMAN

45.86 (~16)

6.13 (6.20)

88

32

7.5E-04

7/18

34

38

0.024

−6.58

Haptoglobin (fragment, alpha 2 chain)

HPT_HUMAN

45.86 (~16)

6.13 (6.20)

80

41

1.9E-04

11/34

31

39

0.004

6.21

Secreted and transmembrane protein 1

SCTM1_HUMAN

27.30

7.00

75

47

6.1E-04

6/9

22

40

0.012

−3.39

Transthyretin

TTHY_HUMAN

15.99

5.52

160

32

2.0E-12

10/27

73

41

0.010

−3.54

Uromodulin

UROM_HUMAN

72.64

5.05

158

57

3.2E-12

18/24

22