Fig. 4

Bioinformatic analysis. a Clustering of identified proteins from tissue samples according to tissue fibrotic stages. The degree of similarity in profiles is shown by colour (base-two logarithmical scale is above the figure). The average protein abundance of the 11 identified proteins (labelled with Cy3 and Cy5 dyes) is calculated relative to internal standard (labelled with Cy2 dye). b Alterations in identified cellular pathways along with fibrosis progression. Alterations in pathways were determined by using expression analysis of Reactome database. c Evidence view of identified liver tissue proteins in String database. (Confidence score > 0.700). Different line colors represent the types of evidence for the association. Green indicates neighborhood. Gray indicates co-expression. Cyan indicates association in current databases. Magenta indicates experimental data. Yellow indicates text mining