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Fig. 1 | Proteome Science

Fig. 1

From: Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors

Fig. 1

Compounds and reagents used in this study. a Versatile reagents based on kinase inhibitors facilitates rapid generation of SNAPtag targeting kinase inhibitor and affinity matrices. KAM has been previously described by our group as compound 3. b Combinatorial library of ABL1 targeting SNAPtag-based bivalent inhibitors. Using SNAPtag as a universal linker, various specificity ligands and ATP-competitive ligands can be displayed from SNAPtag and used in combination to evaluate the influence of each component towards ABL1 binding

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Proteome Science

ISSN: 1477-5956