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Table 1 Assessment of affinity for A-series bivalent inhibitors for selected kinases

From: Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors

Gene Name

KAM RB50 (μM)

A-0 RB50 (μM)

A-1 RB50 (μM)

A-2 RB50 (μM)

ABL1

0.759

>10

1.05

0.070

AAK1

0.008

0.302

6.22

0.815

GSK3A

0.037

1.33

3.26

0.046

GSK3B

0.045

2.05

3.07

0.053

CDK9

0.112

9.03

>10

0.957

NEK9

0.086

5.77

>10

0.514

  1. For affinity assessment of affinity for all kinases see Additional file 1
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ISSN: 1477-5956