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Table 1 Assessment of affinity for A-series bivalent inhibitors for selected kinases

From: Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors

Gene Name KAM RB50 (μM) A-0 RB50 (μM) A-1 RB50 (μM) A-2 RB50 (μM)
ABL1 0.759 >10 1.05 0.070
AAK1 0.008 0.302 6.22 0.815
GSK3A 0.037 1.33 3.26 0.046
GSK3B 0.045 2.05 3.07 0.053
CDK9 0.112 9.03 >10 0.957
NEK9 0.086 5.77 >10 0.514
  1. For affinity assessment of affinity for all kinases see Additional file 1