Fig. 4

Protein-protein interaction (PPI) network and ontology analyses of upregulated proteins in SKOV-3 cells. a. PPI network was built using STRING Ver. 10.0 to analyze the nine increased proteins (indicated in black boxes) by effect of ascites; color circles indicate the main group of proteins related with these proteins at several biological and experimental levels. The intensity for the red halo around each protein indicates the relative abundance obtained from Pax DB for Homo sapiens proteins. Gene Ontology Terms (GOTERM) and annotations for the group of proteins upregulated and their main proteins interacting; gene ontology annotations were performed for a functional enrichment of Biological Process (b), Molecular Function (c) and Cellular Component (d) categories. The groups with a higher quantity of genes related to a specific action on each category were used as a representative action, function or localization under our experimental conditions