Table 2 Classification and metabolic functions of proteins detected in this study. Proteins in italic are involved in glycolysis
Name | Enzyme Nomenclature | Class | Metabolic pathway (KEGG) | Function | Reference |
|---|---|---|---|---|---|
diaminopimelate dehydrogenase | 3.5.1.28 | hydrolases | lysine biosynthesis. Metabolic pathway, Biosynthesis of secondary metabolisms, Biosynthesis of amino acids | cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls | Gao et al., 2017 [39] |
glucose-6-phosphate isomerase | 5.3.1.9 | isomerases | glycolysis/Gluconeogenesis, Pentose phosphate pathway, Starch and sucrose metabolisms, Amino sugar and nucleotide sugar metabolisms, Metabolic pathway, Biosynthesis of secondary metabolisms, Microbial metabolism in diverse environments, Biosynthesis antibiotics, Carbon metabolisms | catalyses the conversion of D-glucose 6-phosphate to D-fructose 6-phosphate | Verhees et al., 2001 [40] |
N-acetylmuramoyl-L-alanine amidase | 3.5.1.28 | hydrolases | cationic antimicrobial peptide CAMP (resistance) | cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala) | Loessner et al., 1995 [41] |
1-phosphofructokinase | 2.7.2.56 | transferases | glycolysis/Gluconeogenesis, Metabolic pathway Biosynthesis of secondary metabolites, Microbial metabolism in diverse environments, Biosynthesis of antibiotics, Carbon metabolism, Biosynthesis of amino acids | catalysed the transfer of a phosphoryl group from adenosinetriphosphate to fructuose-6-phosphate to obtain adenosinetriphosphate and fructose-1,6-bisphophate | Kimmel et al., 2000 [42] |
1-phosphoglycerate kinase | 2.7.1.56 | transferases | glycolysis/Gluconeogenesis, Metabolic pathway Biosynthesis of secondary metabolites, Microbial metabolism in diverse environments, Biosynthesis of antibiotics, Carbon metabolism, Biosynthesis of amino acids | conversion of 1,3-bisphosphate glycerate to 3-phosphoglycerate | Yon et al., 1990 [43] |
beta-hydroxybutyryl-CoA dehydrogenase | 1.1.1.157 | oxidoreductases | – | catalyses the third step in the β-oxidation cycle, production of butyrate | Taylor et al., 2010[44] |
fructose-bisphosphate aldolase, class II | 4.1.2.13 | lyases | glycolysis/Glycogenesis, Pentose phosphate pathway, Fructose and mannose metabolism, Methane metabolism, Metabolic pathway, Biosynthesis of secondary metabolites, Microbial metabolism in diverse environments, Biosynthesis of antibiotics, Carbon metabolism, Biosynthesis of amino acids | catalyses the reversible aldol cleavage or condensation of fructose-1,6-bisphosphate into dihydroxyacetone-phosphate and glyceraldehyde 3-phosphate | Thomson et al., 1998 [45] |
elongation factor Ts | – | – | – | catalyses the enzymatic binding of aminoacylt-RNA to ribosomes | Schwartzbach and Spermulli, 1989 [46] |
glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | oxidoreductases | – | responsible for the interconversion of 1,3-diphosphoglycerate and glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis. Forms exist which utilise NAD (EC:1.2.1.12), NADP (EC:1.2.1.13) or either (EC:1.2.1.59) | Fillinger et al., 2000 [47] |
3-deoxy-D-arabinoheptulosonate-7-phosphate synthase | 2.5.1.54 | transferases | phenylalanine, tyrosine and tryptophan biosynthesis, Metabolic pathway, Biosynthesis of secondary metabolites, Biosynthesis of antibiotics, Biosynthesis of amino acids, Quorum sensing | catalyses the metabolic reactions called the shikimate pathway responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan | Hermann, 2001 [48] |