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Table 1 A. Echocardiographic and B. Morphometric analysis of the left ventricle after four weeks on prescribed diet and morphometric measurements

From: Sex impacts cardiac function and the proteome response to thyroid hormone in aged mice

A Baseline
M CON
Final
M CON
Baseline
M PTU
Final
M PTU
Baseline
M TH
Final
M TH
Baseline
F CON
Final
F CON
Baseline
F PTU
Final
F PTU
Baseline
F TH
Final
F TH
  N = 6 N = 7 N = 6 N = 8 N = 6 N = 8
EDD, mm 3.9±0.1 4.1±0.1 4.3±0.07 4.1±0.1 4.0±0.2 4.4±0.09 4.0±0.07 3.9±0.07 3.9±0.09 4.0±0.06 3.8±0.1 4.0±0.08
ESD, mm 2.8±0.2 3.1±0.1 3.3±0.09 3.2±0.1 3.0±0.2 3.3±0.1 3.0±0.1 3.0±0.08 2.9±0.1 3.1±0.07 2.8±0.2 2.8±0.09
EF, % 50±3.6 47±3.4 48±2 46±2 53±3.7 48±2.6 49±3 45±2 49±2.4 45±2.7 54±3.7 57±2.1
FS, % 25±2.2 24±2.1 24±1 22±.9 27±2.4 25±1.5 24±2 22±1.2 25±1.5 22±1.6 28±2.4 30±1.4
LVPWd, mm 0.81±.03 0.9±0.05 0.86±0.04 0.78±0.04 0.89±0.03 1.3±0.08* 0.88±0.05 0.96±-.04 0.93±0.07 0.81±0.06 0.9±0.07 1.2±0.08*
HR, BPM 480±18 498±23 455±17 371±17** 482±21 585±21** 474±18 514±11 471±15 417±17 504±17 597±12**
B Baseline
M CON
Final
M CON
Baseline
M PTU
Final
M PTU
Baseline
M TH
Final
M TH
Baseline
F CON
Final
F CON
Baseline
F PTU
Final
F PTU
Baseline
F TH
Final
F TH
  N = 8 N = 8 N = 8 N = 9 N = 9 N = 9
BW, g 35±0.7 35±0.8 35±0.9 31±0.6** 34±0.9 33±0.6 29±0.6 30±1 26±0.7 25±0.3 26±0.7 29±1**
HW, mg n/a 169±9 n/a 137±6# n/a 246±6## n/a 146±4 n/a 115±3## n/a 223±10##
HW/TL (mg/mm) n/a 9.7±0.6 n/a 8.0±0.3# n/a 14±0.4## n/a 8.3±0.2 n/a 6.7±.2## n/a 13±0.5##
  1. CON Euthyroid, PTU Hypothyroid, TH Hyperthyroid, EDD left ventricular end diastolic diameter, ESD left ventricular end systolic diameter, FS left ventricular percent fractional shortening, EF left ventricular percent ejection fraction, LVPWd left ventricular posterior wall end diastole, HR heart rate, BPM beats per minute, BW body weight, HW heart weight, TL tibia length. Values are means ± SEM. N = # of animals/sex/treatment. Bolded numbers represent significant changes. Two way ANOVA followed by Tukey post hoc analysis performed on the serial values from the same animals for EDD, ESD, EF, FS, LWPWD, HR and body weight, *p < 0.05, **p < 0.005; one-way ANOVA followed by Tukey post hoc analysis performed on HW and HW/TL values comparing treated group to same sex control, #p < 0.05, ##p < 0.005