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Table 3 Enriched gene ontology (GO) terms for molecular function and KEGG pathway of identified proteins

From: Sex impacts cardiac function and the proteome response to thyroid hormone in aged mice

Category Term Fold Enrichment P Value Bonferroni Benjamini FDR
Molecular Function GO:0051287~NAD binding 35.91 6.00E-07 1.09E-04 1.09E-04 7.41E-04
GO:0016491~oxidoreductase activity 6.54 1.30E-06 2.36E-04 1.18E-04 1.60E-03
GO:0016616~oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 41.15 1.17E-04 0.02 0.01 0.14
GO:0008137~NADH dehydrogenase (ubiquinone) activity 37.62 1.53E-04 0.03 0.01 0.19
GO:0051539~4 iron, 4 sulfur cluster binding 32.92 2.28E-04 0.04 0.01 0.28
GO:0003954~NADH dehydrogenase activity 75.96 6.66E-04 0.11 0.02 0.82
GO:0051536~iron-sulfur cluster binding 20.57 9.15E-04 0.15 0.02 1.12
GO:0008092~cytoskeletal protein binding 19.36 0.001 0.18 0.02 1.34
GO:0000287~magnesium ion binding 8.15 0.003 0.43 0.05 3.71
GO:0050839~cell adhesion molecule binding 13.91 0.02 0.97 0.21 21.07
GO:0019899~enzyme binding 4.29 0.03 0.99 0.26 28.94
KEGG Pathway mmu01100:Metabolic pathways 3.46 8.21E-09 4.93E-07 4.93E-07 8.23E-06
mmu01130:Biosynthesis of antibiotics 10.27 9.09E-09 5.46E-07 2.73E-07 9.11E-06
mmu05012:Parkinson's disease 11.06 9.14E-07 5.49E-05 1.83E-05 9.16E-04
mmu00190:Oxidative phosphorylation 10.54 7.29E-06 4.37E-04 1.09E-04 7.30E-03
mmu05010:Alzheimer's disease 8.28 3.52E-05 2.11E-03 4.23E-04 3.53E-02
mmu05016:Huntington's disease 7.43 7.04E-05 0.004 0.001 0.07
mmu01200:Carbon metabolism 9.51 3.42E-04 0.02 0.00 0.34
mmu00020:Citrate cycle (TCA cycle) 22.98 6.20E-04 0.04 0.00 0.62
mmu04932:Non-alcoholic fatty liver disease (NAFLD) 7.02 0.001 0.08 0.01 1.35
mmu01210:2-Oxocarboxylic acid metabolism 29.02 0.004 0.23 0.03 4.37
mmu04610:Complement and coagulation cascades 9.67 0.01 0.36 0.04 7.24
mmu04260:Cardiac muscle contraction 9.55 0.01 0.37 0.04 7.50
mmu01230:Biosynthesis of amino acids 9.43 0.01 0.38 0.04 7.76