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Table 3 Top 30 DEPs between the BM and non-BM groups

From: Quantitative proteomic analysis of cerebrospinal fluid reveals CD163, A2M and full-length APP as potential diagnostic biomarkers of paediatric bacterial meningitis

Gene name

Protein description

BM/VM

P value

BM/Ctrl

P value

LBP

Lipopolysaccharide-binding protein

34.7476

0.0006

27.9315

0.0030

HPR

Haptoglobin-related protein

34.1995

0.0005

44.0382

0.0004

CD163

Scavenger receptor cysteine-rich type 1 protein M130

19.7130

0.0002

19.6556

0.0002

FCGBP

IgGFc-binding protein

19.3185

0.0001

20.5446

0.0001

VSIG4

Low affinity immunoglobulin gamma Fc region receptor III-A

17.1259

0.0001

16.2035

0.0002

FCGR3A

Low affinity immunoglobulin gamma Fc region receptor III-A

13.7149

0.0000

15.7777

0.0000

FGG

Fibrinogen gamma chain

13.5045

0.0006

14.1276

0.0008

APOM

Apolipoprotein M

12.4151

0.0021

10.9577

0.0040

HP

Haptoglobin

12.3086

0.0276

13.1471

0.0192

F13A1

Coagulation factor XIII A chain

11.4554

0.0044

10.7878

0.0046

CPN2

Carboxypeptidase N subunit 2

10.9681

0.0004

11.8880

0.0000

SERPINA3

Alpha-1-antichymotrypsin

10.2239

0.0020

11.0671

0.0014

CD14

Monocyte differentiation antigen CD14

10.0526

0.0000

11.2716

0.0000

CD5L

CD5 antigen-like

9.9693

0.0016

13.6411

0.0000

A2M

Alpha-2-macroglobulin

9.9481

0.0000

10.3473

0.0000

CNDP1

Beta-Ala-His dipeptidase

0.1948

0.0012

0.2300

0.0106

FAT2

Protocadherin Fat 2

0.2882

0.0020

0.2801

0.0014

CPE

Carboxypeptidase E

0.2943

0.0003

0.3083

0.0006

KLK6

Kallikrein-6

0.3063

0.0016

0.3328

0.0064

TPI1

Triosephosphate isomerase

0.4314

0.0109

0.4548

0.0244

IGSF8

Immunoglobulin superfamily member 8

0.4340

0.0001

0.4832

0.0222

CPQ

Carboxypeptidase Q

0.4603

0.0003

0.4523

0.0159

TPP1

Tripeptidyl-peptidase 1

0.4745

0.0007

0.4844

0.0056

ADAM22

Disintegrin and metalloproteinase domain-containing protein 22

0.5135

0.0073

0.5476

0.0208

SOD3

Extracellular superoxide dismutase [Cu–Zn]

0.5491

0.0024

0.5373

0.0075

DCN

Decorin

0.5561

0.0060

0.5824

0.0200

APP

Amyloid-beta precursor protein

0.5879

0.0329

0.6077

0.0426

CPVL

Probable serine carboxypeptidase CPVL

0.6167

0.0057

0.6104

0.0033

MDH1

Malate dehydrogenase, cytoplasmic

0.6205

0.0062

0.5937

0.0046

CTSD

Cathepsin D

0.6220

0.0039

0.6290

0.0104

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