Fig. 4

The proteins interactions between differential proteins and KEGG pathways. A The protein-protein interaction (PPI) network obtained from the STING database containing 43 nodes and 150 edges. B The PPI of the largest cluster containing 13 nodes and 88 edges. C The top ten significant KEGG enrichment pathways and the interaction network of the proteins interacting with them. D The legends of the pictures upon. The dots represent genes, red represents up-regulated expression, and green represents down-regulated expression. Rounded rectangles of (C) represent signaling pathways. Blue represents higher significance and yellow represents lower significance. The straight lines represent interactions, the solid lines represent protein-protein interactions, and the dashed lines represent metabolic pathways -- protein-protein interactions