Fig. 5
From: Profiles of transcriptome and metabolic pathways after hypobaric hypoxia exposure
Overexpression of ANGPTL4 has an equal effect on the regulation of pathway genes and lipid metabolism caused by Hypobaric Hypoxia. A The overexpression of ANGPTL4 on mRNA levels. B Lipid metabolism-related genes relative mRNA levels after the expression of ANGPTL4, showing the up-regulation of ACACA, LIPE and LPL. Student’s t-test, paired tail, * < 0.05. C Oil red O staining assays validated the overexpression of ANGPTL4 regulates lipid metabolism by increasing the number of lipid droplets in treated cells compared to controls. D IPA predicted pathways based on qRT-PCR results. The predicted pathways are enriched in lipid metabolism, similar to the observations following hypobaric hypoxia treatment