Fig. 5
From: Proteomic analysis of ceftazidime and meropenem-exposed Pseudomonas aeruginosa ATCC 9027
Proposed mechanisms for the development of Caz and Mem resistance. The common resistance mechanisms in Caz and Mem response: 1. Up-regulation of beta-lactamase AmpC, 2) Down-regulation of Porin D (OprD), 3) Up-regulation of efflux pump system (MexAB-OprM) and 4) Down-regulation of SOS response (RecA). The distinguished mechanisms: Type VI secretion proteins (TssC1 and Hcp1) showed their important role in Caz resistance, while Azurin (Azu) was important response in Mem resistance