Figure 1

Representative two-dimensional protein expression patterns of three different brain regions (striatum, midbrain and cortex) showing significantly altered protein spots (blue circled, unpaired student T-test, n = 6, p < 0.05. Over 20% of expression alteration). Over 5000 protein spots could be detected on each protein pattern. The gel insets demonstrate that there was little overlap of altered protein isoforms among the three brain regions (gel images from PINK1-KO mice).