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Table 2 Functional pathways (KEGG) that were overrepresented in PINK1-KO induced protein expression alterations of different brain regions

From: Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease

Up-regulated proteins in striatum:  
KEGG pathway Number of proteins Multiple test adjusted p-value
Metabolic pathways Sucla2, Mdh2, Ckb, Gss, Idh2, Echs1, Ckmt1, Tpi1, Ldhb, Aldoc, Taldo1 2.66 e-13
Citrate cycle (TCA cycle) Sucla2, Mdh2, Idh2 4.02E-07
Propanoate metabolism Sucla2, Ldhb, Echs1 4.02E-07
Glycolysis/Gluconeogenesis Tpi1, Ldhb, Aldoc 1.42E-05
Down-regulated proteins in midbrain:  
KEGG pathway Number of proteins Multiple test adjusted p-value
Metabolic pathways Ldha, Aldoa, Eno2, Pdhb, Mecr, Ckmt1, Suclg1, Gapdh, Pafah1b2, Mdh1 3.30 e-10
Glycolysis/Gluconeogenesis Gapdh, Ldha, Aldoa, Eno2, Pdhb 4.40E-09
Citrate cycle (TCA cycle) Suclg1, Pdhb, Mdh1 8.11E-07
Pyruvate metabolism Ldha, Pdhb, Mdh1 1.44E-06
Up-regulated proteins in cortex:  
KEGG pathway Number of proteins Multiple test adjusted p-value
Metabolic pathways Cs, Auh, Aldoa, Gss, Abat, Atp5c1, Pgk1, Eno1, Tkt, Gapdh, Tpi1, Ldhb, Nme1, Got1, Taldo1 4.28E-18
Glycolysis/Gluconeogenesis Pgk1, Eno1, Gapdh, Tpi1, Ldhb, Aldoa 6.93E-11
Pentose phosphate pathway Tkt, Aldoa, Taldo1 1.55E-06
Regulation of actin cytoskeleton Actg1, Actb, Pfn1 3.00E-04