Table 2 Functional pathways (KEGG) that were overrepresented in PINK1-KO induced protein expression alterations of different brain regions
Up-regulated proteins in striatum: | Â | |
|---|---|---|
KEGG pathway | Number of proteins | Multiple test adjusted p-value |
Metabolic pathways | Sucla2, Mdh2, Ckb, Gss, Idh2, Echs1, Ckmt1, Tpi1, Ldhb, Aldoc, Taldo1 | 2.66 e-13 |
Citrate cycle (TCA cycle) | Sucla2, Mdh2, Idh2 | 4.02E-07 |
Propanoate metabolism | Sucla2, Ldhb, Echs1 | 4.02E-07 |
Glycolysis/Gluconeogenesis | Tpi1, Ldhb, Aldoc | 1.42E-05 |
Down-regulated proteins in midbrain: | Â | |
KEGG pathway | Number of proteins | Multiple test adjusted p-value |
Metabolic pathways | Ldha, Aldoa, Eno2, Pdhb, Mecr, Ckmt1, Suclg1, Gapdh, Pafah1b2, Mdh1 | 3.30 e-10 |
Glycolysis/Gluconeogenesis | Gapdh, Ldha, Aldoa, Eno2, Pdhb | 4.40E-09 |
Citrate cycle (TCA cycle) | Suclg1, Pdhb, Mdh1 | 8.11E-07 |
Pyruvate metabolism | Ldha, Pdhb, Mdh1 | 1.44E-06 |
Up-regulated proteins in cortex: | Â | |
KEGG pathway | Number of proteins | Multiple test adjusted p-value |
Metabolic pathways | Cs, Auh, Aldoa, Gss, Abat, Atp5c1, Pgk1, Eno1, Tkt, Gapdh, Tpi1, Ldhb, Nme1, Got1, Taldo1 | 4.28E-18 |
Glycolysis/Gluconeogenesis | Pgk1, Eno1, Gapdh, Tpi1, Ldhb, Aldoa | 6.93E-11 |
Pentose phosphate pathway | Tkt, Aldoa, Taldo1 | 1.55E-06 |
Regulation of actin cytoskeleton | Actg1, Actb, Pfn1 | 3.00E-04 |