Table 2 Differentially expressed proteins discovered with 2D gel proteomics with a p-value < 0.05

Zinc α 2-glycoprotein (ZAG)

P25311

1a

40

1.9 up

< 0.05

NS

NS

NS

NS

2

NS

Most basic glycoform

Zinc α 2-glycoprotein (ZAG)

P25311

1b

40

1.5 up

< 0.05

NS

NS

NS

NS

2

111/4

Most basic glycoform

Zinc α 2-glycoprotein (ZAG)

P25311

1c

40

1.3 up

0.06

NS

NS

NS

NS

2

88/6

NS but trending

Histidine-rich glycoprotein (HRG)

P04196

1d

~ 35

1.7 up

< 0.02

NS

NS

2.9 up

< 0.002

2

161/4

Putative cleavage product

Unidentified Series

n/a

1e

~ 40

1.5 down

< 0.05

NS

NS

NS

NS

–

n/a

Low abundant species

Haptoglobin (Hpt) heavy chain

P00738

2a

40

2.0 up

< 0.01

NS

NS

2.2 up

< 0.02

2

238/13

Summation of variants

Haptoglobin (Hpt) mid chain

P00738

2b

16

NS

NS

NS

NS

NS

NS

2

a

NS changing subunit of Hpt

Haptoglobin (Hpt) light chain

P00738

2c

9

2.4 up

< 0.02

NS

NS

NS

NS

2

a

Summation of variants

Vitamin D binding protein (VDBP)

P02774

3b

~ 50

NS

NS

Cleavage products

Vitamin D binding protein (VDBP)

P02774

3c

~ 40

NS

NS

Multiple cleavage products

Vitamin D binding protein (VDBP)

P02774

3d

~ 10

NS

NS

Multiple cleavage products

Inter α trypsin inhibitor heavy chain H4 (ITIH4)

Q14624

3e

~ 12

1.3 up

< 0.05

NS

NS

NS

NS

3

428/5

C-term clevage product

Complement factor 1(CFI)

P05156

3f

~ 53

NS

NS

2.5 up

< 0.01

2.6 down

< 0.02

2

64/2

Putative cleavage product

Complement factor 1(CFI)

P05156

3 g

~ 53

NS

NS

2.0 up

< 0.001

2.4 down

< 0.03

2

78/2

Putative cleavage product

Complement factor 1(CFI)

P05156

3 h

~ 53

NS

NS

3.6 up

0.056

3.1 down

< 0.03

2

127/4

Putative cleavage product

Complement factor 1(CFI)

P05156

3i

~ 53

NS

NS

4.0 up

< 0.1

3.1 down

0.058

2

69/1

NS but trending

Inter α trypsin inhibitor heavy chain H4 (ITIH4)

Q14624

4a

~ 40

1.3 up

< 0.05

1.5 up

< 0.02

NS

NS

3

890/14

N-term cleavage product

C-reactive binding protein (CRP)

P02741

4b

25

3.2 up

0.19

NS

NS

NS

NS

1

96/2

NS change

C-reactive binding protein (CRP)

P02741

4c

25

2.9 up

0.09

NS

NS

NS

NS

1

NS

NS change

C-reactive binding protein (CRP)

P02741

4d

25

2.4 up

0.18

NS

NS

NS

NS

1

NS

NS change

C-reactive binding protein (CRP)

P02741

4e

25

2.2 up

0.06

NS

NS

NS

NS

1

NS

NS but trending

α 1-antitrypsin (α1AT)

P01009

5a

~ 47

3.3

< 0.02

NS

NS

NS

NS

2

86/3

Apolipoprotein E (ApoE)

P02649

5b

34

1.5 up

< 0.02

NS

NS

NS

NS

2

149/7

Epsilon 4 proxy