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  1. Under conditions of salt stress, plants respond by initiating phosphorylation cascades. Many key phosphorylation events occur at the membrane. However, to date only limited sites have been identified that are ...

    Authors: Jue-Liang Hsu, Lan-Yu Wang, Shu-Ying Wang, Ching-Huang Lin, Kuo-Chieh Ho, Fong-Ku Shi and Ing-Feng Chang

    Citation: Proteome Science 2009 7:42

    Content type: Research

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  2. Dorsal root ganglion (DRG) neurons are primary sensory neurons that conduct neuronal impulses related to pain, touch and temperature senses. Plasma membrane (PM) of DRG cells plays important roles in their fun...

    Authors: Xia Xiong, Sha Huang, Hai Zhang, Jianjun Li, Jianying Shen, Jixian Xiong, Yong Lin, Liping Jiang, Xianchun Wang and Sonping Liang

    Citation: Proteome Science 2009 7:41

    Content type: Research

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  3. The broad range in growth observed in response to growth hormone (GH) treatment is mainly caused by individual variations in both GH secretion and GH sensitivity. Individual GH responsiveness can be estimated ...

    Authors: Björn Andersson, Gunnel Hellgren, Andreas FM Nierop, Ze'ev Hochberg and Kerstin Albertsson-Wikland

    Citation: Proteome Science 2009 7:40

    Content type: Research

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  4. Hepatitis E, caused by the hepatitis E virus (HEV), is endemic to developing countries where it manifests as waterborne outbreaks and sporadic cases. Though generally self-limited with a low mortality rate, so...

    Authors: Shikha Taneja, Somdutta Sen, Vijay K Gupta, Rakesh Aggarwal and Shahid Jameel

    Citation: Proteome Science 2009 7:39

    Content type: Research

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  5. Two-dimensional gel electrophoresis (2-DE) is a powerful method to study protein expression and function in living organisms and diseases. This technique, however, has not been applied to avian bursa of Fabric...

    Authors: Yongping Wu, Jiyong Zhou, Xin Zhang, Xiaojuan Zheng, Xuetao Jiang, Lixue Shi, Wei Yin and Junhua Wang

    Citation: Proteome Science 2009 7:38

    Content type: Methodology

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  6. Acinetobacter baumannii is a nosocomial pathogen that has been associated with outbreak infections in hospitals. Despite increasing awareness about this bacterium, its proteome remains poorly characterised, howe...

    Authors: Nelson C Soares, Maria P Cabral, José R Parreira, Carmen Gayoso, Maria J Barba and Germán Bou

    Citation: Proteome Science 2009 7:37

    Content type: Research

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  7. Decoding of the liver proteome is subject of intense research, but hampered by methodological constraints. We recently developed an improved protocol for studying rat liver proteins based on 2-DE-MALDI-TOF-MS ...

    Authors: Giuseppe Gazzana and Jürgen Borlak

    Citation: Proteome Science 2009 7:35

    Content type: Research

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  8. Only a minority of patients with advanced non-small cell lung cancer (NSCLC) benefit from chemotherapy. Serum peptide profiling of NSCLC patients was performed to investigate patterns associated with treatment...

    Authors: Johannes Voortman, Thang V Pham, Jaco C Knol, Giuseppe Giaccone and Connie R Jimenez

    Citation: Proteome Science 2009 7:34

    Content type: Research

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  9. The present study examined the changes in protein expression in Spirulina platensis upon exposure to high temperature, with the changes in expression analyzed at the subcellular level. In addition, the transcript...

    Authors: Apiradee Hongsthong, Matura Sirijuntarut, Rayakorn Yutthanasirikul, Jittisak Senachak, Pavinee Kurdrid, Supapon Cheevadhanarak and Morakot Tanticharoen

    Citation: Proteome Science 2009 7:33

    Content type: Research

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  10. Neutrophils are the most abundant leukocytes in peripheral blood and represent one of the most important elements of innate immunity. Recent subcellular proteomic studies have focused on the identification of ...

    Authors: Gisele G Tomazella, Idalete da Silva, Helen J Laure, José C Rosa, Roger Chammas, Harald G Wiker, Gustavo A de Souza and Lewis J Greene

    Citation: Proteome Science 2009 7:32

    Content type: Research

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  11. Down syndrome (DS), caused by trisomy of human chromosome 21 (HSA21), is the most common genetic birth defect. Congenital heart defects (CHD) are seen in 40% of DS children, and >50% of all atrioventricular ca...

    Authors: Frédéric Delom, Emma Burt, Alex Hoischen, Joris Veltman, Jürgen Groet, Finbarr E Cotter and Dean Nizetic

    Citation: Proteome Science 2009 7:31

    Content type: Research

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  12. Enterobacter sp. YSU is resistant to several different heavy metal salts, including selenite. A previous study using M-9 minimal medium showed that when the selenite concentration was 100,000 times higher than t...

    Authors: Ashley Jasenec, Nathaniel Barasa, Samatha Kulkarni, Nabeel Shaik, Swarnalatha Moparthi, Venkataramana Konda and Jonathan Caguiat

    Citation: Proteome Science 2009 7:30

    Content type: Research

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  13. Infection with high-risk type human papilloma viruses (HPVs) is associated with cervical carcinomas and with a subset of head and neck squamous cell carcinomas. Viral E6 and E7 oncogenes cooperate to achieve c...

    Authors: Mark A Merkley, Ellen Hildebrandt, Robert H Podolsky, Hilal Arnouk, Daron G Ferris, William S Dynan and Hubert Stöppler

    Citation: Proteome Science 2009 7:29

    Content type: Research

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  14. Although much is known about signal transduction downstream of insulin-like growth factor-1 (IGF-1), relatively little is known about the global changes in protein expression induced by this hormone. In this s...

    Authors: Charles C King, Kathyrn Bouic and Theodore Friedmann

    Citation: Proteome Science 2009 7:28

    Content type: Research

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  15. Predicting the function of an unknown protein is an essential goal in bioinformatics. Sequence similarity-based approaches are widely used for function prediction; however, they are often inadequate in the abs...

    Authors: Bum Ju Lee, Moon Sun Shin, Young Joon Oh, Hae Seok Oh and Keun Ho Ryu

    Citation: Proteome Science 2009 7:27

    Content type: Research

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  16. Prednisone, one of the most highly prescribed drugs, has well characterized effects on gene transcription mediated by the glucocorticoid receptor. These effects are typically occurring on the scale of hours. P...

    Authors: Erica KM Reeves, Heather Gordish-Dressman, Eric P Hoffman and Yetrib Hathout

    Citation: Proteome Science 2009 7:26

    Content type: Research

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  17. Abnormal activation of protease activities during experimental autoimmune encephalomyelitis (EAE) in rats, a rodent model of multiple sclerosis, have been implicated in either the direct destruction of myelin ...

    Authors: Mohit Raja Jain, Shengjie Bian, Tong Liu, Jun Hu, Stella Elkabes and Hong Li

    Citation: Proteome Science 2009 7:25

    Content type: Research

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  18. The in vitro stationary phase proteome of the human pathogen Shigella dysenteriae serotype 1 (SD1) was quantitatively analyzed in Coomassie Blue G250 (CBB)-stained 2D gels. More than four hundred and fifty protei...

    Authors: Srilatha Kuntumalla, John C Braisted, Shih-Ting Huang, Prashanth P Parmar, David J Clark, Hamid Alami, Quanshun Zhang, Arthur Donohue-Rolfe, Saul Tzipori, Robert D Fleischmann, Scott N Peterson and Rembert Pieper

    Citation: Proteome Science 2009 7:22

    Content type: Research

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  19. Ruk/CIN85 is a mammalian adaptor molecule with three SH3 domains. Using its SH3 domains Ruk/CIN85 can cluster multiple proteins and protein complexes, and, consequently, facilitates organisation of elaborate p...

    Authors: Serhiy Havrylov, Yuriy Rzhepetskyy, Agata Malinowska, Lyudmyla Drobot and Maria Jolanta Redowicz

    Citation: Proteome Science 2009 7:21

    Content type: Research

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  20. Mitochondrial proteins are central to various metabolic activities and are key regulators of apoptosis. Disturbance of mitochondrial proteins is therefore often associated with disease. Large scale protein dat...

    Authors: Johan Palmfeldt, Søren Vang, Vibeke Stenbroen, Christina B Pedersen, Jane H Christensen, Peter Bross and Niels Gregersen

    Citation: Proteome Science 2009 7:20

    Content type: Research

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  21. Mass spectrometry is increasingly being used to discover proteins or protein profiles associated with disease. Experimental design of mass-spectrometry studies has come under close scrutiny and the importance ...

    Authors: Wouter Wegdam, Perry D Moerland, Marrije R Buist, Emiel Ver Loren van Themaat, Boris Bleijlevens, Huub CJ Hoefsloot, Chris G de Koster and Johannes MFG Aerts

    Citation: Proteome Science 2009 7:19

    Content type: Research

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  22. Plant growth-promoting bacteria can alleviate the inhibitory effects of various heavy metals on plant growth, via decreasing levels of stress-induced ethylene. However, little has been done to detect any mecha...

    Authors: Zhenyu Cheng, Yi-Yun C Wei, Wilson WL Sung, Bernard R Glick and Brendan J McConkey

    Citation: Proteome Science 2009 7:18

    Content type: Research

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  23. Cervical-vaginal fluid (CVF) plays an important role in the prevention of gynecological infections, although little is known about the contribution of CVF proteins to the immunity of the lower female genital t...

    Authors: Geert Zegels, Geert AA Van Raemdonck, Edmond P Coen, Wiebren AA Tjalma and Xaveer WM Van Ostade

    Citation: Proteome Science 2009 7:17

    Content type: Research

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  24. Many putative disease blood biomarkers discovered in genomic and proteomic studies await validation in large clinically annotated cohorts of patient samples. ELISA assays require large quantities of precious b...

    Authors: Adriana Aguilar-Mahecha, Christiane Cantin, Maureen O'Connor-McCourt, Andre Nantel and Mark Basik

    Citation: Proteome Science 2009 7:15

    Content type: Methodology

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  25. Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) is a commensal of horses and an opportunistic pathogen in many animals and humans. Some strains produce copious amounts of hyaluronic acid, making S. zo...

    Authors: Esteban Marcellin, Christian W Gruber, Colin Archer, David J Craik and Lars K Nielsen

    Citation: Proteome Science 2009 7:13

    Content type: Research

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  26. Ozone is a major component of air pollution. Exposure to this powerful oxidizing agent can cause or exacerbate many lung conditions, especially those involving innate immunity. Surfactant protein-A (SP-A) play...

    Authors: Rizwanul Haque, Todd M Umstead, Willard M Freeman, Joanna Floros and David S Phelps

    Citation: Proteome Science 2009 7:12

    Content type: Research

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  27. The small intestine is an important human organ that plays a central role in many physiological functions including digestion, absorption, secretion and defense. Duodenal pathologies include, for instance, the...

    Authors: Maria Paola Simula, Renato Cannizzaro, Maria Dolores Marin, Alessandro Pavan, Giuseppe Toffoli, Vincenzo Canzonieri and Valli De Re

    Citation: Proteome Science 2009 7:10

    Content type: Research

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  28. Mass spectrometers can produce a large number of tandem mass spectra. They are unfortunately noise-contaminated. Noises can affect the quality of tandem mass spectra and thus increase the false positives and f...

    Authors: Jiarui Ding, Jinhong Shi, Guy G Poirier and Fang-Xiang Wu

    Citation: Proteome Science 2009 7:9

    Content type: Research

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  29. Acute lymphoblastic leukemia (ALL) is a common form of cancer in children. Currently, bone marrow biopsy is used for diagnosis. Noninvasive biomarkers for the early diagnosis of pediatric ALL are urgently need...

    Authors: Linan Shi, Jun Zhang, Peng Wu, Kai Feng, Jing Li, Zhensheng Xie, Peng Xue, Tanxi Cai, Ziyou Cui, Xiulan Chen, Junjie Hou, Jianzhong Zhang and Fuquan Yang

    Citation: Proteome Science 2009 7:7

    Content type: Research

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  30. Spectral counting is a shotgun proteomics approach comprising the identification and relative quantitation of thousands of proteins in complex mixtures. However, this strategy generates bewildering amounts of ...

    Authors: Paulo C Carvalho, Juliana SG Fischer, Emily I Chen, Gilberto B Domont, Maria GC Carvalho, Wim M Degrave, John R Yates III and Valmir C Barbosa

    Citation: Proteome Science 2009 7:6

    Content type: Methodology

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    The Related Article to this article has been published in Nature Protocols 2015 11:BFnprot2015133

  31. Yersinia pestis proteins were sequentially extracted from crude membranes with a high salt buffer (2.5 M NaBr), an alkaline solution (180 mM Na2CO3, pH 11.3) and membrane denaturants (8 M urea, 2 M thiourea and ...

    Authors: Rembert Pieper, Shih-Ting Huang, David J Clark, Jeffrey M Robinson, Hamid Alami, Prashanth P Parmar, Moo-Jin Suh, Srilatha Kuntumalla, Christine L Bunai, Robert D Perry, Robert D Fleischmann and Scott N Peterson

    Citation: Proteome Science 2009 7:5

    Content type: Research

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  32. Macrophages are involved in a number of key physiological processes and complex responses such as inflammatory, immunological, infectious diseases and iron homeostasis. These cells are specialised for iron sto...

    Authors: Rita Polati, Annalisa Castagna, Alessandra Bossi, Natascia Campostrini, Federica Zaninotto, Anna Maria Timperio, Lello Zolla, Oliviero Olivieri, Roberto Corrocher and Domenico Girelli

    Citation: Proteome Science 2009 7:4

    Content type: Methodology

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  33. Markers of pancreatic cancer invasion were investigated in two clonal populations of the cell line, MiaPaCa-2, Clone #3 (high invasion) and Clone #8 (low invasion) using proteomic profiling of an in vitro model o...

    Authors: Naomi Walsh, Norma O'Donovan, Susan Kennedy, Michael Henry, Paula Meleady, Martin Clynes and Paul Dowling

    Citation: Proteome Science 2009 7:3

    Content type: Research

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  34. TGF-β acts as an antiproliferative factor in normal epithelial cells and at early stages of oncogenesis. However, later in tumor development TGF-β can become tumor promoting through mechanisms including the in...

    Authors: Jennifer J Hill, Tammy-Lynn Tremblay, Christiane Cantin, Maureen O'Connor-McCourt, John F Kelly and Anne EG Lenferink

    Citation: Proteome Science 2009 7:2

    Content type: Research

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  35. Heat stress (HS) and related illnesses are a major concern in military, sports, and fire brigadiers. HS results in physiologic responses of increased temperature, heart rate and sweating. In heat stroke, infla...

    Authors: Ganapathy Rajaseger, Chin Leong Lim, Lee Koon Wui, Padmanabhan Saravanan, Kai Tang, Ponnampalam Gopalakrishnakone, Yap Eric Pen-huat, Jia Lu and Moochhala M Shabbir

    Citation: Proteome Science 2009 7:1

    Content type: Research

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  36. A fundamental pathogenic feature of the fungus Histoplasma capsulatum is its ability to evade innate and adaptive immune defenses. Once ingested by macrophages the organism is faced with several hostile environme...

    Authors: Michael S Winters, Daniel S Spellman, Qilin Chan, Francisco J Gomez, Margarita Hernandez, Brittany Catron, Alan G Smulian, Thomas A Neubert and George S Deepe Jr

    Citation: Proteome Science 2008 6:36

    Content type: Research

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  37. The broad range in growth observed in short prepubertal children receiving the same growth hormone (GH) dose is due to individual variation in GH responsiveness. This study used a pharmaco-proteomic approach i...

    Authors: Gunnel Hellgren, Björn Andersson, Andreas FM Nierop, Jovanna Dahlgren, Ze'ev Hochberg and Kerstin Albertsson-Wikland

    Citation: Proteome Science 2008 6:35

    Content type: Research

    Published on:

  38. The underlying pathways that drive retinal neurogenesis and synaptogenesis are still relatively poorly understood. Protein expression analysis can provide direct insight into these complex developmental proces...

    Authors: Sorcha Finnegan, Joanne L Robson, Mildred Wylie, Adrienne Healy, Alan W Stitt and William J Curry

    Citation: Proteome Science 2008 6:34

    Content type: Research

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  39. An important step in the proteomics of solid tumors, including breast cancer, consists of efficiently extracting most of proteins in the tumor specimen. For this purpose, Radio-Immunoprecipitation Assay (RIPA)...

    Authors: Lambert CM Ngoka

    Citation: Proteome Science 2008 6:30

    Content type: Research

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  40. Oxidoreductases are enzymes that catalyze many redox reactions in normal and neoplastic cells. Their actions include catalysis of the transformation of free, neutral oxygen gas into oxygen free radicals, super...

    Authors: Lambert CM Ngoka

    Citation: Proteome Science 2008 6:29

    Content type: Research

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