Cohen P: Protein kinases — the major drug targets of the twenty-first century? Nat Rev Drug Discov 2002, 1: 309–315.
Article
CAS
PubMed
Google Scholar
Parsons SJ, Parsons JT: Src family kinases, key regulators of signal transduction. Oncogene 2004, 23: 7906–7909.
Article
CAS
PubMed
Google Scholar
Noble MEM: Protein kinase inhibitors: insights into drug design from structure. Science 2004, 303: 1800–1805.
Article
CAS
PubMed
Google Scholar
Page BDG: Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity. J Med Chem 2012, 55: 1047–1055.
Article
CAS
PubMed
Google Scholar
Vu CB: Recent advances in the design and synthesis of SH2 inhibitors of Src, Grb2 and ZAP-70. Curr Med Chem 2000, 7: 1081–1100.
Article
CAS
PubMed
Google Scholar
Zhang J, Yang PL, Gray NS: Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer 2009, 9: 28–39.
Article
PubMed
Google Scholar
Zhang Y, Zhang J, Yuan C, Hard RL, Park I-H, Li C, Bell C, Pei D: Simultaneous binding of two peptidyl ligands by a Src homology 2 domain. Biochemistry 2011, 50: 7637–7646.
Article
PubMed Central
CAS
PubMed
Google Scholar
Uniprot Consortium: Update on activities at the Universal Protein Resource (UniProt) in 2013. Nucleic Acids Res 2012, 41: D43.
Article
Google Scholar
Liu BA, Jablonowski K, Raina M, Arcé M, Pawson T, Nash PD: The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling. Mol Cell 2006, 22: 851–868.
Article
PubMed
Google Scholar
Akinleye A, Avvaru P, Furqan M, Song Y, Liu D: Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics. J Hematol Oncol 2013, 6: 88.
Article
PubMed Central
PubMed
Google Scholar
Kraskouskaya D, Duodu E, Arpin CC, Gunning PT: Progress towards the development of SH2 domain inhibitors. Chem Soc Rev 2013, 42: 3337.
Article
CAS
PubMed
Google Scholar
Bantscheff M, Eberhard D, Abraham Y, Bastuck S, Boesche M, Hobson S, Mathieson T, Perrin J, Raida M, Rau C, Reader V, Sweetman G, Bauer A, Bouwmeester T, Hopf C, Kruse U, Neubauer G, Ramsden N, Rick J, Kuster B, Drewes G: Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat Biotechnol 2007, 25: 1035–1044.
Article
CAS
PubMed
Google Scholar
Wiśniewski JR, Zougman A, Nagaraj N, Mann M: Universal sample preparation method for proteome analysis. Nat Meth 2009, 6: 359–362.
Article
Google Scholar
Tinti M, Kiemer L, Costa S, Miller ML, Sacco F, Olsen JV, Carducci M, Paoluzi S, Langone F, Workman CT, Blom N, Machida K, Thompson CM, Schutkowski M, Brunak S, Mann M, Mayer BJ, Castagnoli L, Cesareni G: The SH2 domain interaction landscape. Cell Reports 2013, 3: 1293–1305.
Article
PubMed Central
CAS
PubMed
Google Scholar
Blagoev B, Ong S-E, Kratchmarova I, Mann M: Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics. Nat Biotechnol 2004, 22: 1139–1145.
Article
CAS
PubMed
Google Scholar
Schulze WX, Deng L, Mann M: Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol 2005, 1: E1-E13.
Article
Google Scholar
Lemeer S, Bluwstein A, Wu Z, Leberfinger J, Müller K, Kramer K, Kuster B: Phosphotyrosine mediated protein interactions of the discoidin domain receptor 1. J Proteomics 2012, 75: 3465–3477.
Article
CAS
PubMed
Google Scholar
Charifson PS: Peptide ligands of pp60c-src SH2 domains: a thermodynamic and structural study. Biochemistry 1997, 36: 6283–6293.
Article
CAS
PubMed
Google Scholar
Schirle M, Bantscheff M, Kuster B: Mass spectrometry-based proteomics in preclinical drug discovery. Chem Biol 2012, 19: 72–84.
Article
CAS
PubMed
Google Scholar
Gay B, Suarez S, Caravatti G, Furet P, Meyer T, Schoepfer J: Selective GRB2 SH2 inhibitors as anti-Ras therapy. Int J Cancer 1999, 83: 235–241.
Article
CAS
PubMed
Google Scholar
Tong L, Warren TC, King J, Betageri R, Rose J, Jakes S: Crystal structures of the human p56Ick SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 Å and 1.8 Å resolution. J Med Biol 1996, 256: 601–610.
CAS
Google Scholar
Imhof D: Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains: critical roles of residues beyond the pY+3 position. J Biol Chem 2006, 281: 20271–20282.
Article
CAS
PubMed
Google Scholar
Quartararo JS, Wu P, Kritzer JA: Peptide bicycles that inhibit the Grb2 SH2 domain. ChemBioChem 2012, 13: 1490–1496.
Article
PubMed Central
CAS
PubMed
Google Scholar
Trott O, Olson AJ: AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 2009, 31: 455–461.
Google Scholar
Zhou S, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, Neel BG, Birge RB, Fajardo JE, Chou MM, Hanafusa H, Schaffhausen B, Cantley LC: SH2 domains recognize specific phosphopeptide sequences. Cell Reports 1993, 72: 767–778.
Google Scholar
Yokomatsu T, Murano T, Suemune K, Shibuya S: Facile synthesis of aryl(difluoromethyl)phosphonates through CuBr-mediated cross coupling reactions of [(diethoxyphosphinyl)difluoromethyl]zinc bromide with aryl iodides. Tetrahedron 1997, 53: 815–822.
Article
CAS
Google Scholar
Qabar MN, Urban J, Kahn M: A facile solution and solid phase synthesis of phosphotyrosine mimetic l-4-[diethylphosphono(difluoromethyl)]-phenylalanine (F
2
Pmp(EtO)
2
) derivatives. Tetrahedron 1997, 53: 11171–11178.
Article
CAS
Google Scholar
Gholami AM, Hahne H, Wu Z, Auer FJ, Meng C, Wilhelm M, Kuster B: Global proteome analysis of the NCI-60 cell line panel. Cell Rep 2013, 4: 609–620.
Article
CAS
Google Scholar
Waksman G, Shoelson SE, Pant N, Cowburn D, Kuriyan J: Binding of a high affinity phosphotyrosyl peptide to the Src 5SH26 domain: crystal structures of the complexed and peptide-free forms. Cell 1993, 72: 779–790.
Article
CAS
PubMed
Google Scholar
Miled N, Yan Y, Hon W-C, Perisic O, Zvelebil M, Inbar Y, Schneidman-Duhovny D, Wolfson HJ, Backer JM, Williams RL: Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 2007, 317: 239–242.
Article
CAS
PubMed
Google Scholar
Nagar B, Hantschel O, Seeliger M, Davies JM, Weis WI, Superti-Furga G, Kuriyan J: Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol Cell 2006, 21: 787–798.
Article
CAS
PubMed
Google Scholar
Geering B, Cutillas PR, Nock G, Gharbi SI, Vanhaesebroeck B: Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers. Proc Natl Acad Sci U S A 2007, 114: 7809–7814.
Article
Google Scholar
Günther UL, Liu Y, Sanford D, Bachovchin WW, Schaffhausen B: NMR analysis of interactions of a phosphatidylinositol 3′-kinase SH2 domain with phosphotyrosine peptides reveals interdependence of major binding sites. Biochemistry 1996, 35: 15570–15581.
Article
PubMed
Google Scholar
Stankovic CJ, Surendran N, Lunney EA, Plummer MS, Para KS, Shahripour A, Fergus JH, Marks JS, Herrera R, Hubbell SE, Humblet C, Saltiel AR, Stewart BH, Sawyer TK: The role of 4-phosphonodifluoromethyl- and 4-phosphono-phenylalanine in the selectivity and cellular uptake of 5SH26 domain ligands. Bioorg Med Chem Lett 1997, 7: 1909–1914.
Article
CAS
Google Scholar
O’Brien R, Rugman P, Renzoni D, Layton M, Handa R, Hilyard K, Waterfield MD, Driscoll PC, Ladbury JE: Alternative modes of binding of proteins with tandem SH2 domains. Protein Sci 2000, 9: 570–579.
Article
PubMed Central
PubMed
Google Scholar
Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE: UCSF Chimera? A visualization system for exploratory research and analysis. J Comput Chem 2004, 25: 1605–1612.
Article
CAS
PubMed
Google Scholar
Cox J, Mann M: MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol 2008, 26: 1367–1372.
Article
CAS
PubMed
Google Scholar
Cox J, Neuhauser N, Michalski A, Scheltema RA, Olsen JV, Mann M: Andromeda: a peptide search engine integrated into the MaxQuant environment. J Proteome Res 2011, 10: 1794–1805.
Article
CAS
PubMed
Google Scholar