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  1. Decoding of the liver proteome is subject of intense research, but hampered by methodological constraints. We recently developed an improved protocol for studying rat liver proteins based on 2-DE-MALDI-TOF-MS ...

    Authors: Giuseppe Gazzana and Jürgen Borlak
    Citation: Proteome Science 2009 7:35
    Content type: Research Published on:

  2. Only a minority of patients with advanced non-small cell lung cancer (NSCLC) benefit from chemotherapy. Serum peptide profiling of NSCLC patients was performed to investigate patterns associated with treatment...

    Authors: Johannes Voortman, Thang V Pham, Jaco C Knol, Giuseppe Giaccone and Connie R Jimenez
    Citation: Proteome Science 2009 7:34
    Content type: Research Published on:

  3. The present study examined the changes in protein expression in Spirulina platensis upon exposure to high temperature, with the changes in expression analyzed at the subcellular level. In addition, the transcript...

    Authors: Apiradee Hongsthong, Matura Sirijuntarut, Rayakorn Yutthanasirikul, Jittisak Senachak, Pavinee Kurdrid, Supapon Cheevadhanarak and Morakot Tanticharoen
    Citation: Proteome Science 2009 7:33
    Content type: Research Published on:

  4. Neutrophils are the most abundant leukocytes in peripheral blood and represent one of the most important elements of innate immunity. Recent subcellular proteomic studies have focused on the identification of ...

    Authors: Gisele G Tomazella, Idalete da Silva, Helen J Laure, José C Rosa, Roger Chammas, Harald G Wiker, Gustavo A de Souza and Lewis J Greene
    Citation: Proteome Science 2009 7:32
    Content type: Research Published on:

  5. Down syndrome (DS), caused by trisomy of human chromosome 21 (HSA21), is the most common genetic birth defect. Congenital heart defects (CHD) are seen in 40% of DS children, and >50% of all atrioventricular ca...

    Authors: Frédéric Delom, Emma Burt, Alex Hoischen, Joris Veltman, Jürgen Groet, Finbarr E Cotter and Dean Nizetic
    Citation: Proteome Science 2009 7:31
    Content type: Research Published on:

  6. Enterobacter sp. YSU is resistant to several different heavy metal salts, including selenite. A previous study using M-9 minimal medium showed that when the selenite concentration was 100,000 times higher than t...

    Authors: Ashley Jasenec, Nathaniel Barasa, Samatha Kulkarni, Nabeel Shaik, Swarnalatha Moparthi, Venkataramana Konda and Jonathan Caguiat
    Citation: Proteome Science 2009 7:30
    Content type: Research Published on:

  7. Infection with high-risk type human papilloma viruses (HPVs) is associated with cervical carcinomas and with a subset of head and neck squamous cell carcinomas. Viral E6 and E7 oncogenes cooperate to achieve c...

    Authors: Mark A Merkley, Ellen Hildebrandt, Robert H Podolsky, Hilal Arnouk, Daron G Ferris, William S Dynan and Hubert Stöppler
    Citation: Proteome Science 2009 7:29
    Content type: Research Published on:

  8. Although much is known about signal transduction downstream of insulin-like growth factor-1 (IGF-1), relatively little is known about the global changes in protein expression induced by this hormone. In this s...

    Authors: Charles C King, Kathyrn Bouic and Theodore Friedmann
    Citation: Proteome Science 2009 7:28
    Content type: Research Published on:

  9. Predicting the function of an unknown protein is an essential goal in bioinformatics. Sequence similarity-based approaches are widely used for function prediction; however, they are often inadequate in the abs...

    Authors: Bum Ju Lee, Moon Sun Shin, Young Joon Oh, Hae Seok Oh and Keun Ho Ryu
    Citation: Proteome Science 2009 7:27
    Content type: Research Published on:

  10. Prednisone, one of the most highly prescribed drugs, has well characterized effects on gene transcription mediated by the glucocorticoid receptor. These effects are typically occurring on the scale of hours. P...

    Authors: Erica KM Reeves, Heather Gordish-Dressman, Eric P Hoffman and Yetrib Hathout
    Citation: Proteome Science 2009 7:26
    Content type: Research Published on:

  11. Abnormal activation of protease activities during experimental autoimmune encephalomyelitis (EAE) in rats, a rodent model of multiple sclerosis, have been implicated in either the direct destruction of myelin ...

    Authors: Mohit Raja Jain, Shengjie Bian, Tong Liu, Jun Hu, Stella Elkabes and Hong Li
    Citation: Proteome Science 2009 7:25
    Content type: Research Published on:

  14. The in vitro stationary phase proteome of the human pathogen Shigella dysenteriae serotype 1 (SD1) was quantitatively analyzed in Coomassie Blue G250 (CBB)-stained 2D gels. More than four hundred and fifty protei...

    Authors: Srilatha Kuntumalla, John C Braisted, Shih-Ting Huang, Prashanth P Parmar, David J Clark, Hamid Alami, Quanshun Zhang, Arthur Donohue-Rolfe, Saul Tzipori, Robert D Fleischmann, Scott N Peterson and Rembert Pieper
    Citation: Proteome Science 2009 7:22
    Content type: Research Published on:

  15. Ruk/CIN85 is a mammalian adaptor molecule with three SH3 domains. Using its SH3 domains Ruk/CIN85 can cluster multiple proteins and protein complexes, and, consequently, facilitates organisation of elaborate p...

    Authors: Serhiy Havrylov, Yuriy Rzhepetskyy, Agata Malinowska, Lyudmyla Drobot and Maria Jolanta Redowicz
    Citation: Proteome Science 2009 7:21
    Content type: Research Published on:

  16. Mitochondrial proteins are central to various metabolic activities and are key regulators of apoptosis. Disturbance of mitochondrial proteins is therefore often associated with disease. Large scale protein dat...

    Authors: Johan Palmfeldt, Søren Vang, Vibeke Stenbroen, Christina B Pedersen, Jane H Christensen, Peter Bross and Niels Gregersen
    Citation: Proteome Science 2009 7:20
    Content type: Research Published on:

  17. Mass spectrometry is increasingly being used to discover proteins or protein profiles associated with disease. Experimental design of mass-spectrometry studies has come under close scrutiny and the importance ...

    Authors: Wouter Wegdam, Perry D Moerland, Marrije R Buist, Emiel Ver Loren van Themaat, Boris Bleijlevens, Huub CJ Hoefsloot, Chris G de Koster and Johannes MFG Aerts
    Citation: Proteome Science 2009 7:19
    Content type: Research Published on:

  18. Plant growth-promoting bacteria can alleviate the inhibitory effects of various heavy metals on plant growth, via decreasing levels of stress-induced ethylene. However, little has been done to detect any mecha...

    Authors: Zhenyu Cheng, Yi-Yun C Wei, Wilson WL Sung, Bernard R Glick and Brendan J McConkey
    Citation: Proteome Science 2009 7:18
    Content type: Research Published on:

  19. Cervical-vaginal fluid (CVF) plays an important role in the prevention of gynecological infections, although little is known about the contribution of CVF proteins to the immunity of the lower female genital t...

    Authors: Geert Zegels, Geert AA Van Raemdonck, Edmond P Coen, Wiebren AA Tjalma and Xaveer WM Van Ostade
    Citation: Proteome Science 2009 7:17
    Content type: Research Published on:

  21. Many putative disease blood biomarkers discovered in genomic and proteomic studies await validation in large clinically annotated cohorts of patient samples. ELISA assays require large quantities of precious b...

    Authors: Adriana Aguilar-Mahecha, Christiane Cantin, Maureen O'Connor-McCourt, Andre Nantel and Mark Basik
    Citation: Proteome Science 2009 7:15
    Content type: Methodology Published on:

  23. Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) is a commensal of horses and an opportunistic pathogen in many animals and humans. Some strains produce copious amounts of hyaluronic acid, making S. zo...

    Authors: Esteban Marcellin, Christian W Gruber, Colin Archer, David J Craik and Lars K Nielsen
    Citation: Proteome Science 2009 7:13
    Content type: Research Published on:

  24. Ozone is a major component of air pollution. Exposure to this powerful oxidizing agent can cause or exacerbate many lung conditions, especially those involving innate immunity. Surfactant protein-A (SP-A) play...

    Authors: Rizwanul Haque, Todd M Umstead, Willard M Freeman, Joanna Floros and David S Phelps
    Citation: Proteome Science 2009 7:12
    Content type: Research Published on:

  26. The small intestine is an important human organ that plays a central role in many physiological functions including digestion, absorption, secretion and defense. Duodenal pathologies include, for instance, the...

    Authors: Maria Paola Simula, Renato Cannizzaro, Maria Dolores Marin, Alessandro Pavan, Giuseppe Toffoli, Vincenzo Canzonieri and Valli De Re
    Citation: Proteome Science 2009 7:10
    Content type: Research Published on:

  27. Mass spectrometers can produce a large number of tandem mass spectra. They are unfortunately noise-contaminated. Noises can affect the quality of tandem mass spectra and thus increase the false positives and f...

    Authors: Jiarui Ding, Jinhong Shi, Guy G Poirier and Fang-Xiang Wu
    Citation: Proteome Science 2009 7:9
    Content type: Research Published on:

  29. Acute lymphoblastic leukemia (ALL) is a common form of cancer in children. Currently, bone marrow biopsy is used for diagnosis. Noninvasive biomarkers for the early diagnosis of pediatric ALL are urgently need...

    Authors: Linan Shi, Jun Zhang, Peng Wu, Kai Feng, Jing Li, Zhensheng Xie, Peng Xue, Tanxi Cai, Ziyou Cui, Xiulan Chen, Junjie Hou, Jianzhong Zhang and Fuquan Yang
    Citation: Proteome Science 2009 7:7
    Content type: Research Published on:

  30. Spectral counting is a shotgun proteomics approach comprising the identification and relative quantitation of thousands of proteins in complex mixtures. However, this strategy generates bewildering amounts of ...

    Authors: Paulo C Carvalho, Juliana SG Fischer, Emily I Chen, Gilberto B Domont, Maria GC Carvalho, Wim M Degrave, John R Yates III and Valmir C Barbosa
    Citation: Proteome Science 2009 7:6
    Content type: Methodology Published on:

    The Related Article to this article has been published in Nature Protocols 2015 11:nprot.2015.133

  31. Yersinia pestis proteins were sequentially extracted from crude membranes with a high salt buffer (2.5 M NaBr), an alkaline solution (180 mM Na2CO3, pH 11.3) and membrane denaturants (8 M urea, 2 M thiourea and ...

    Authors: Rembert Pieper, Shih-Ting Huang, David J Clark, Jeffrey M Robinson, Hamid Alami, Prashanth P Parmar, Moo-Jin Suh, Srilatha Kuntumalla, Christine L Bunai, Robert D Perry, Robert D Fleischmann and Scott N Peterson
    Citation: Proteome Science 2009 7:5
    Content type: Research Published on:

  32. Macrophages are involved in a number of key physiological processes and complex responses such as inflammatory, immunological, infectious diseases and iron homeostasis. These cells are specialised for iron sto...

    Authors: Rita Polati, Annalisa Castagna, Alessandra Bossi, Natascia Campostrini, Federica Zaninotto, Anna Maria Timperio, Lello Zolla, Oliviero Olivieri, Roberto Corrocher and Domenico Girelli
    Citation: Proteome Science 2009 7:4
    Content type: Methodology Published on:

  33. Markers of pancreatic cancer invasion were investigated in two clonal populations of the cell line, MiaPaCa-2, Clone #3 (high invasion) and Clone #8 (low invasion) using proteomic profiling of an in vitro model o...

    Authors: Naomi Walsh, Norma O'Donovan, Susan Kennedy, Michael Henry, Paula Meleady, Martin Clynes and Paul Dowling
    Citation: Proteome Science 2009 7:3
    Content type: Research Published on:

  34. TGF-β acts as an antiproliferative factor in normal epithelial cells and at early stages of oncogenesis. However, later in tumor development TGF-β can become tumor promoting through mechanisms including the in...

    Authors: Jennifer J Hill, Tammy-Lynn Tremblay, Christiane Cantin, Maureen O'Connor-McCourt, John F Kelly and Anne EG Lenferink
    Citation: Proteome Science 2009 7:2
    Content type: Research Published on:

  35. Heat stress (HS) and related illnesses are a major concern in military, sports, and fire brigadiers. HS results in physiologic responses of increased temperature, heart rate and sweating. In heat stroke, infla...

    Authors: Ganapathy Rajaseger, Chin Leong Lim, Lee Koon Wui, Padmanabhan Saravanan, Kai Tang, Ponnampalam Gopalakrishnakone, Yap Eric Pen-huat, Jia Lu and Moochhala M Shabbir
    Citation: Proteome Science 2009 7:1
    Content type: Research Published on:

  36. A fundamental pathogenic feature of the fungus Histoplasma capsulatum is its ability to evade innate and adaptive immune defenses. Once ingested by macrophages the organism is faced with several hostile environme...

    Authors: Michael S Winters, Daniel S Spellman, Qilin Chan, Francisco J Gomez, Margarita Hernandez, Brittany Catron, Alan G Smulian, Thomas A Neubert and George S Deepe Jr
    Citation: Proteome Science 2008 6:36
    Content type: Research Published on:

  37. The broad range in growth observed in short prepubertal children receiving the same growth hormone (GH) dose is due to individual variation in GH responsiveness. This study used a pharmaco-proteomic approach i...

    Authors: Gunnel Hellgren, Björn Andersson, Andreas FM Nierop, Jovanna Dahlgren, Ze'ev Hochberg and Kerstin Albertsson-Wikland
    Citation: Proteome Science 2008 6:35
    Content type: Research Published on:

  38. The underlying pathways that drive retinal neurogenesis and synaptogenesis are still relatively poorly understood. Protein expression analysis can provide direct insight into these complex developmental proces...

    Authors: Sorcha Finnegan, Joanne L Robson, Mildred Wylie, Adrienne Healy, Alan W Stitt and William J Curry
    Citation: Proteome Science 2008 6:34
    Content type: Research Published on:

  42. An important step in the proteomics of solid tumors, including breast cancer, consists of efficiently extracting most of proteins in the tumor specimen. For this purpose, Radio-Immunoprecipitation Assay (RIPA)...

    Authors: Lambert CM Ngoka
    Citation: Proteome Science 2008 6:30
    Content type: Research Published on:

  43. Oxidoreductases are enzymes that catalyze many redox reactions in normal and neoplastic cells. Their actions include catalysis of the transformation of free, neutral oxygen gas into oxygen free radicals, super...

    Authors: Lambert CM Ngoka
    Citation: Proteome Science 2008 6:29
    Content type: Research Published on:

  44. Hepcidin is a 25-residue peptide hormone crucial to iron homeostasis. It is essential to measure the concentration of hepcidin in cells, tissues and body fluids to understand its mechanisms and roles in physio...

    Authors: Douglas G Ward, Keith Roberts, Paul Stonelake, Patrick Goon, Cleidiane G Zampronio, Ashley Martin, Philip J Johnson, Tariq Iqbal and Chris Tselepis
    Citation: Proteome Science 2008 6:28
    Content type: Research Published on:

  46. The ProteomeLabâ„¢ PF 2D platform is a relatively new approach to global protein profiling. Herein, it was used for investigation of plasma proteome changes in amyotrophic lateral sclerosis (ALS) patients before...

    Authors: Joshua D Schlautman, Wojciech Rozek, Robert Stetler, R Lee Mosley, Howard E Gendelman and Pawel Ciborowski
    Citation: Proteome Science 2008 6:26
    Content type: Methodology Published on:

  47. Unravelling the serum proteome is the subject of intensified research. In this regard, two-dimensional electrophoresis coupled with MALDI MS analysis is still one of the most commonly used method. Despite some...

    Authors: Maria Stella Ritorto and Jürgen Borlak
    Citation: Proteome Science 2008 6:25
    Content type: Research Published on:

  48. Trypanosoma cruzi, a flagellate protozoan, is the etiological agent of Chagas disease, a chronic illness that causes irreversible damage to heart and digestive tract in humans. Previous 2-DE analyses of T. cruzi

    Authors: Adriana D Magalhães, Sébastien Charneau, Jaime Paba, Rafael AP Guércio, Antonio RL Teixeira, Jaime M Santana, Marcelo V Sousa and Carlos AO Ricart
    Citation: Proteome Science 2008 6:24
    Content type: Research Published on:

  49. The bovine spongiform encephalopathy (BSE) epidemic and the emergence of a new human variant of Creutzfeldt-Jakob Disease (vCJD) have led to profound changes in the production and trade of agricultural goods. ...

    Authors: Sharon LR Simon, Lise Lamoureux, Margot Plews, Michael Stobart, Jillian LeMaistre, Ute Ziegler, Catherine Graham, Stefanie Czub, Martin Groschup and J David Knox
    Citation: Proteome Science 2008 6:23
    Content type: Research Published on:
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