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  1. Research

    Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors

    Identifying selective kinase inhibitors remains a major challenge. The design of bivalent inhibitors provides a rational strategy for accessing potent and selective inhibitors. While bivalent kinase inhibitors...

    Margaret L. Wong, Jason Murphy, Edmund Harrington, Carrie M. Gower, Rishi K. Jain, Markus Schirle and Jason R. Thomas

    Proteome Science 2017 15:17

    Published on: 17 July 2017

  2. Review

    Tetrazine ligation for chemical proteomics

    Determining small molecule—target protein interaction is essential for the chemical proteomics. One of the most important keys to explore biological system in chemical proteomics field is finding first-class m...

    Kyungtae Kang, Jongmin Park and Eunha Kim

    Proteome Science 2017 15:15

    Published on: 26 June 2017

  3. Research

    The hepatocyte proteome in organotypic rat liver models and the influence of the local microenvironment

    Liver models that closely mimic the in vivo microenvironment are useful for understanding liver functions, capabilities, and intercellular communication processes. Three-dimensional (3D) liver models assembled...

    Lucas T. Vu, Sophia M. Orbach, W. Keith Ray, Margaret E. Cassin, Padmavathy Rajagopalan and Richard F. Helm

    Proteome Science 2017 15:12

    Published on: 20 June 2017

  4. Research

    Merging clinical chemistry biomarker data with a COPD database - building a clinical infrastructure for proteomic studies

    Data from biological samples and medical evaluations plays an essential part in clinical decision making. This data is equally important in clinical studies and it is critical to have an infrastructure that en...

    Jonatan Eriksson, Simone Andersson, Roger Appelqvist, Elisabet Wieslander, Mikael Truedsson, May Bugge, Johan Malm, Magnus Dahlbäck, Bo Andersson, Thomas E. Fehniger and György Marko-Varga

    Proteome Science 2017 15:8

    Published on: 21 April 2017

  5. Research

    Proteomic profiling of HBV infected liver biopsies with different fibrotic stages

    Hepatitis B virus (HBV) is a global health problem, and infected patients if left untreated may develop cirrhosis and eventually hepatocellular carcinoma. This study aims to enlighten pathways associated with ...

    Seyma Katrinli, Kamil Ozdil, Abdurrahman Sahin, Oguzhan Ozturk, Gozde Kir, Ahmet Tarik Baykal, Emel Akgun, Omer Sinan Sarac, Mehmet Sokmen, H. Levent Doğanay and Gizem Dinler Doğanay

    Proteome Science 2017 15:7

    Published on: 20 April 2017

  6. Research

    Proteomic analysis of microparticles isolated from malaria positive blood samples

    Malaria continues to be a great public health concern due to the significant mortality and morbidity associated with the disease especially in developing countries. Microparticles (MPs), also called plasma mem...

    Samuel Antwi-Baffour, Jonathan Kofi Adjei, Francis Agyemang-Yeboah, Max Annani-Akollor, Ransford Kyeremeh, George Awuku Asare and Ben Gyan

    Proteome Science 2017 15:5

    Published on: 24 March 2017

  7. Research

    Protein profiles of hatchery egg shell membrane

    Eggshells which consist largely of calcareous outer shell and shell membranes, constitute a significant part of poultry hatchery waste. The shell membranes (ESM) not only contain proteins that originate from e...

    N. C. Rath, R. Liyanage, S. K. Makkar and J. O. Lay Jr.

    Proteome Science 2017 15:4

    Published on: 3 March 2017

  8. Research

    Overgrazing induces alterations in the hepatic proteome of sheep (Ovis aries): an iTRAQ-based quantitative proteomic analysis

    The degradation of the steppe of Inner Mongolia, due to overgrazing, has resulted in ecosystem damage as well as extensive reductions in sheep production. The growth performance of sheep is greatly reduced bec...

    Weibo Ren, Xiangyang Hou, Yuqing Wang, Warwick Badgery, Xiliang Li, Yong Ding, Huiqin Guo, Zinian Wu, Ningning Hu, Lingqi Kong, Chun Chang, Chao Jiang and Jize Zhang

    Proteome Science 2017 15:2

    Published on: 5 January 2017

  9. Research

    Proteomic based approach for characterizing 4-hydroxy-2-nonenal induced oxidation of buffalo (Bubalus bubalis) and goat (Capra hircus) meat myoglobins

    Myoglobin (Mb) is a sarcoplasmic heme protein primarily responsible for meat color and its chemistry is species specific. 4-hydroxy-2-nonenal (HNE) is a cytotoxic lipid derived aldehyde detected in meat and wa...

    Naveena B. Maheswarappa, K. Usha Rani, Y. Praveen Kumar, Vinayak V. Kulkarni and Srikanth Rapole

    Proteome Science 2016 14:18

    Published on: 16 November 2016

  10. Research

    iTRAQ-based proteomic analysis of myofibrillar contents and relevant synthesis and proteolytic proteins in soleus muscle of hibernating Daurian ground squirrels (Spermophilus dauricus)

    Daurian ground squirrels (Spermophilus dauricus) deviate from significant increase of protein catabolism and loss of myofibrillar contents during long period of hibernation inactivity.

    Hui Chang, Shan-Feng Jiang, Kai Dang, Hui-Ping Wang, Shen-Hui Xu and Yun-Fang Gao

    Proteome Science 2016 14:16

    Published on: 8 November 2016

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