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  1. Osteoarthritis (OA) is a chronic degenerative disease of the articular cartilage, and its diagnosis is based on symptoms and radiological signs that are only present in the late stages of the disease. Due to t...

    Authors: Nancy Marbella Parra-Torres, Febe Elena Cázares-Raga and Juan Bautista Kouri
    Citation: Proteome Science 2014 12:55
    Content type: Research article Published on:

  2. Transcription factors bind to response elements on the promoter regions of genes to regulate transcriptional activity. One of the major problems with identifying transcription factors is their low abundance re...

    Authors: Linda I Nagore, YanWen Zhou, Robert J Nadeau, YinShan Jia and Harry W Jarrett
    Citation: Proteome Science 2014 12:53
    Content type: Research article Published on:

  3. Pancreatic cancer development is associated with characteristic alterations like desmoplastic reaction and immune escape which are mediated by the cell-cell communication mechanism and by the microenvironment ...

    Authors: Susanne Klein-Scory, Mahnaz Moradian Tehrani, Christina Eilert-Micus, Kamila A Adamczyk, Nathalie Wojtalewicz, Martina Schnölzer, Stephan A Hahn, Wolff Schmiegel and Irmgard Schwarte-Waldhoff
    Citation: Proteome Science 2014 12:50
    Content type: Research article Published on:

  4. The cytokine MIF (Macrophage Migration Inhibitory Factor) has diverse physiological roles and is present at elevated concentrations in numerous disease states. However, its molecular heterogeneity has not been...

    Authors: Nisha D Sherma, Chad R Borges, Olgica Trenchevska, Jason W Jarvis, Douglas S Rehder, Paul E Oran, Randall W Nelson and Dobrin Nedelkov
    Citation: Proteome Science 2014 12:52
    Content type: Research article Published on:

  5. Acute coronary syndrome is the major cause of death in developed countries. Despite its high prevalence, there is still a strong need for new biomarkers which permit faster and more accurate diagnostics and ne...

    Authors: Carlos M Laborde, Sergio Alonso-Orgaz, Laura Mourino-Alvarez, José Moreu, Fernando Vivanco, Luis R Padial and María G Barderas
    Citation: Proteome Science 2014 12:43
    Content type: Research Published on:

  6. The rapid progress of proteomics over the past years has allowed the discovery of a large number of potential biomarker candidates to improve early tumor diagnosis and therapeutic response, thus being further ...

    Authors: Ionela Daniela Popescu, Elena Codrici, Lucian Albulescu, Simona Mihai, Ana-Maria Enciu, Radu Albulescu and Cristiana Pistol Tanase
    Citation: Proteome Science 2014 12:47
    Content type: Research article Published on:

  7. The zootechnical performance of three different commercial feeds and their impact on liver and serum proteins of gilthead sea bream (Sparus aurata, L.) were assessed in a 12 week feeding trial. The three feeds, n...

    Authors: Stefania Ghisaura, Roberto Anedda, Daniela Pagnozzi, Grazia Biosa, Simona Spada, Elia Bonaglini, Roberto Cappuccinelli, Tonina Roggio, Sergio Uzzau and Maria Filippa Addis
    Citation: Proteome Science 2014 12:44
    Content type: Research article Published on:

  8. Visceral leishmaniasis (VL) is a deadly parasitic diseases caused by Leishmania donovani; it is a major health problem in many countries. A lack of proper understanding of the disease biology, poor diagnostic met...

    Authors: Arup Kumar Bag, Sutapa Saha, Shyam Sundar, Bibhuti Saha, Abhijit Chakrabarti and Chitra Mandal
    Citation: Proteome Science 2014 12:48
    Content type: Research article Published on:

  9. The persistence of minimal residual disease (MRD) during therapy is the strongest adverse prognostic factor in acute lymphocytic leukemia (ALL). This study was to identify serum candidate peptides for monitori...

    Authors: Ju Bai, Aili He, Chen Huang, Juan Yang, Wanggang Zhang, Jianli Wang, Yun Yang, Pengyu Zhang, Yang Zhang and Fuling Zhou
    Citation: Proteome Science 2014 12:49
    Content type: Research article Published on:

    The Correction to this article has been published in Proteome Science 2020 18:9

  10. Sporadic inclusion body myositis (s-IBM) is the most commonly occurring acquired inflammatory myopathy in elderly people (>45 years); however, pathogenic mechanisms are poorly understood and diagnostic tools a...

    Authors: Ke Li, Chuanqiang Pu, Xusheng Huang, Jiexiao Liu, Yanling Mao and Xianghui Lu
    Citation: Proteome Science 2014 12:45
    Content type: Research article Published on:

  11. Protein phosphorylation is considered a key event in signal transduction. Peripheral blood mononuclear cells (PBMCs) are a critical component of the immune system. The analysis of PBMCs phosphoproteome might h...

    Authors: Maria Teresa Rocchetti, Michela Alfarano, Leonarda Varraso, Salvatore Di Paolo, Massimo Papale, Elena Ranieri, Giuseppe Grandaliano and Loreto Gesualdo
    Citation: Proteome Science 2014 12:46
    Content type: Research article Published on:

  13. Many human diseases are correlated with the dysregulation of signal transduction processes. One of the most important protein interaction domains in the context of signal transduction is the Src homology 2 (SH...

    Authors: Michael Höfener, Stephanie Heinzlmeir, Bernhard Kuster and Norbert Sewald
    Citation: Proteome Science 2014 12:41
    Content type: Research Published on:

  14. We have witnessed significant progress in gene-based approaches to cancer prognostication, promising early intervention for high-risk patients and avoidance of overtreatment for low-risk patients. However, the...

    Authors: Michail Shipitsin, Clayton Small, Eldar Giladi, Summar Siddiqui, Sibgat Choudhury, Sadiq Hussain, Yi E Huang, Hua Chang, David L Rimm, David M Berman, Thomas P Nifong and Peter Blume-Jensen
    Citation: Proteome Science 2014 12:40
    Content type: Research Published on:

  15. Organotypic tumor spheroids, a 3D in vitro model derived from patient tumor material, preserve tissue heterogeneity and retain structural tissue elements, thus replicating the in vivo tumor more closely than comm...

    Authors: Uros Rajcevic, Jaco C Knol, Sander Piersma, Sébastien Bougnaud, Fred Fack, Eirik Sundlisaeter, Karl Søndenaa, Reidar Myklebust, Thang V Pham, Simone P Niclou and Connie R Jiménez
    Citation: Proteome Science 2014 12:39
    Content type: Research Published on:

  16. Haemophilus parasuis is the causative agent of Glässer’s disease characterized by polyserositis, arthritis, and meningitis in pig, leading to serious economic loss. Despite many years of study, virulence factors ...

    Authors: Luhua Zhang, Yiping Wen, Ying Li, Xingliang Wei, Xuefeng Yan, Xintian Wen, Rui Wu, Xiaobo Huang, Yong Huang, Qigui Yan, Mafeng Liu and Sanjie Cao
    Citation: Proteome Science 2014 12:38
    Content type: Research Published on:

  17. Somatic embryogenesis is a complex process regulated by numerous factors. The identification of proteins that are differentially expressed during plant development could result in the development of molecular ...

    Authors: Ellen de Moura Vale, Angelo Schuabb Heringer, Tatiana Barroso, André Teixeira da Silva Ferreira, Monique Nunes da Costa, Jonas Enrique Aguilar Perales, Claudete Santa-Catarina and Vanildo Silveira
    Citation: Proteome Science 2014 12:37
    Content type: Research Published on:

  18. It is possible to identify thousands of phosphopeptides and –proteins in a single experiment with mass spectrometry-based phosphoproteomics. However, a current bottleneck is the downstream data analysis which ...

    Authors: Sandra Söderholm, Petteri Hintsanen, Tiina Öhman, Tero Aittokallio and Tuula A Nyman
    Citation: Proteome Science 2014 12:36
    Content type: Methodology Published on:

  19. Suberin is a recalcitrant plant biopolymer composed of a polyphenolic and a polyaliphatic domain. Although suberin contributes to a significant portion of soil organic matter, the biological process of suberin...

    Authors: Doaa Komeil, Rebeca Padilla-Reynaud, Sylvain Lerat, Anne-Marie Simao-Beaunoir and Carole Beaulieu
    Citation: Proteome Science 2014 12:35
    Content type: Research Published on:

  22. A more specific and early diagnostics for prostate cancer (PCa) is highly desirable. In this study, being inflammation the focus of our effort, serum protein profiles were analyzed in order to investigate if t...

    Authors: Stefania Bergamini, Elisa Bellei, Luca Reggiani Bonetti, Emanuela Monari, Aurora Cuoghi, Francesco Borelli, Maria Chiara Sighinolfi, Giampaolo Bianchi, Tomris Ozben and Aldo Tomasi
    Citation: Proteome Science 2014 12:32
    Content type: Research Published on:

  23. Although protein phosphorylation is an important post-translational modification affecting protein function and metabolism, dynamic changes in this process during ontogenesis remain unexplored in woody angiosp...

    Authors: Yan Wang, Yi Wang, Yong Bo Zhao, Dong Mei Chen, Zhen Hai Han and Xin Zhong Zhang
    Citation: Proteome Science 2014 12:31
    Content type: Research Published on:

  24. Atherosclerosis is considered a progressive disease that affects arteries that bring blood to the heart, to the brain and to the lower end. It derives from endothelial dysfunction and inflammation, which play ...

    Authors: Alvaro Montoya-Rodríguez, Jorge Milán-Carrillo, Vermont P Dia, Cuauhtémoc Reyes-Moreno and Elvira González de Mejía
    Citation: Proteome Science 2014 12:30
    Content type: Research Published on:

  25. Aeromonas salmonicida is an important fish pathogen that produces a wide and varied array of virulence factors. Here we used iron deprivation by addition of the chelator 2’2-dipyridyl to induce the expression of ...

    Authors: Simon Menanteau-Ledouble, Julia Kattlun, Katharina Nöbauer and Mansour El-Matbouli
    Citation: Proteome Science 2014 12:29
    Content type: Research Published on:

  27. Vascular endothelial growth factor (VEGF) is a critical pro-angiogenic factor, found in a number of cancers, and a target of therapy. It is typically assessed by immunohistochemistry (IHC) in clinical research...

    Authors: Joon-Yong Chung, Till Braunschweig, Seung-Mo Hong, David S Kwon, Soo-Heang Eo, HyungJun Cho and Stephen M Hewitt
    Citation: Proteome Science 2014 12:27
    Content type: Methodology Published on:

  29. The myotendinous junction is a specialized structure of the muscle fibre enriched in mechanosensing complexes, including costameric proteins and core elements of the z-disc. Here, laser capture microdissection...

    Authors: Tugba Can, Laura Faas, David A Ashford, Adam Dowle, Jerry Thomas, Peter O’Toole and Gonzalo Blanco
    Citation: Proteome Science 2014 12:25
    Content type: Research Published on:

  30. Lipid lowering agent such as agonists of peroxisome proliferator-activated receptors (PPAR) are suggested as neuroprotective agents and may protect from the sequelae of brain ischemic stroke. Although the demo...

    Authors: Patrick Gelé, Valérie Vingtdeux, Camille Potey, Hervé Drobecq, Antoine Ghestem, Patricia Melnyk, Luc Buée, Nicolas Sergeant and Régis Bordet
    Citation: Proteome Science 2014 12:24
    Content type: Research Published on:

  31. Tight spatio-temporal signaling of cytoskeletal and adhesion dynamics is required for localized membrane protrusion that drives directed cell migration. Different ensembles of proteins are therefore likely to ...

    Authors: Georgios Fengos, Alexander Schmidt, Katrin Martin, Erika Fluri, Ruedi Aebersold, Dagmar Iber and Olivier Pertz
    Citation: Proteome Science 2014 12:23
    Content type: Research Published on:

  32. Hepatic resection is the preferred treatment for huge hepatocellular carcinoma (>10 cm in diameter; H-HCC). However, the patients with H-HCC suffer from poor prognosis due to the early recurrence/metastasis. T...

    Authors: Xinhui Huang, Yongyi Zeng, Xiaohua Xing, Jinhua Zeng, Yunzhen Gao, Zhixiong Cai, Bo Xu, Xiaolong Liu, Aimin Huang and Jingfeng Liu
    Citation: Proteome Science 2014 12:22
    Content type: Research Published on:

  33. The biofilm forming bacterium Staphylococcus aureus is responsible for maladies ranging from severe skin infection to major diseases such as bacteremia, endocarditis and osteomyelitis. A flow displacement system ...

    Authors: Nazrul Islam, Yonghyun Kim, Julia M Ross and Mark R Marten
    Citation: Proteome Science 2014 12:21
    Content type: Research Published on:

  34. Idiopathic Parkinson’s disease is marked by degeneration of dopamine neurons projecting from the substantia nigra to the striatum. Although proteins expressed by the target striatum can positively affect the v...

    Authors: Heidi R Fuller, Maica Llavero Hurtado, Thomas M Wishart and Monte A Gates
    Citation: Proteome Science 2014 12:20
    Content type: Research Published on:

  35. Milk contains a range of proteins of moderate or low abundance that contribute to host defence. Characterisation of these proteins, the extent to which their abundance is regulated by pathogenic stimuli, and t...

    Authors: Grant A Smolenski, Marita K Broadhurst, Kerst Stelwagen, Brendan J Haigh and Thomas T Wheeler
    Citation: Proteome Science 2014 12:19
    Content type: Research Published on:

  37. Allergies are nearly always triggered by protein molecules and the majority of individuals with documented immunologic reactions to foods exhibit IgE hypersensitivity reactions. In this study we aimed to under...

    Authors: Cátia Fonseca, Sébastien Planchon, Carla Pinheiro, Jenny Renaut, Cândido Pinto Ricardo, M Margarida Oliveira and Rita Batista
    Citation: Proteome Science 2014 12:17
    Content type: Research Published on:

  39. Despite extensive research on hepatic cells precursors and their differentiated states, much remains to be learned about the mechanism underlying the self-renewal and differentiation.

    Authors: Claudia Montaldo, Carmine Mancone, Alice Conigliaro, Angela Maria Cozzolino, Valeria de Nonno and Marco Tripodi
    Citation: Proteome Science 2014 12:15
    Content type: Research Published on:

  40. The length of time that a protein remains available to perform its function is significantly influenced by its turnover rate. Knowing the turnover rate of proteins involved in different processes is important ...

    Authors: Marie-Laure A Sauer, Bing Xu and Fedora Sutton
    Citation: Proteome Science 2014 12:14
    Content type: Methodology Published on:

  42. Scientists have injected endotoxin into animals to investigate and understand various pathologies and novel therapies for several decades. Recent observations have shown that there is selective susceptibility to

    Authors: Saul Chemonges, John-Paul Tung and John F Fraser
    Citation: Proteome Science 2014 12:12
    Content type: Review Published on:

  43. Proteomic analysis was performed in post-nuclear supernatant (PNS) and Percoll-purified membranes (PM) prepared from fore brain cortex of rats exposed to increasing doses of morphine (10–50 mg/kg) for 10 days.

    Authors: Hana Ujcikova, Adam Eckhardt, Dmytro Kagan, Lenka Roubalova and Petr Svoboda
    Citation: Proteome Science 2014 12:11
    Content type: Research Published on:

  44. Blast wounds often involve diverse tissue types and require substantial time and treatment for appropriate healing. Some of these subsequent wounds become colonized with bacteria requiring a better understandi...

    Authors: Brett A Chromy, Angela Eldridge, Jonathan A Forsberg, Trevor S Brown, Benjamin C Kirkup, Eric Elster and Paul Luciw
    Citation: Proteome Science 2014 12:10
    Content type: Methodology Published on:

  46. Certain wheat gluten proteins form large protein polymers that are extractable in 0.5% SDS only after sonication. Although there is a strong relationship between the amounts of these polymers in the flour and ...

    Authors: William H Vensel, Charlene K Tanaka and Susan B Altenbach
    Citation: Proteome Science 2014 12:8
    Content type: Research Published on:

  47. Apple, an invaluable fruit crop worldwide, is often prone to infection by pathogenic fungi. Identification of potentially resistance-conferring apple proteins is one of the most important aims for studying app...

    Authors: Miaomiao Li, Jianhua Xu, Zonghao Qiu, Juan Zhang, Fengwang Ma and Junke Zhang
    Citation: Proteome Science 2014 12:7
    Content type: Research Published on:

  48. Fast Fixation is necessary to study real-time protein-protein interactions under physiological conditions. Fast formaldehyde cross-linking can fix transient and weak protein interactions, thereby reducing the ...

    Authors: Lisi Zhu, Menglin Li, Lilong Wei, Xuejiao Liu, Jianrui Yin and Youhe Gao
    Citation: Proteome Science 2014 12:6
    Content type: Research Published on:

  49. With the promise of disease modifying treatments, there is a need for more specific diagnosis and prognosis of Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Plasma biomarkers are likely to be u...

    Authors: Fei Song, Anne Poljak, Nicole A Kochan, Mark Raftery, Henry Brodaty, George A Smythe and Perminder S Sachdev
    Citation: Proteome Science 2014 12:5
    Content type: Research Published on:

  50. The complexity of protein glycosylation makes it difficult to characterize glycosylation patterns on a proteomic scale. In this study, we developed an integrated strategy for comparatively analyzing N-glycosyl...

    Authors: Ji Wang, Chuang Zhou, Wei Zhang, Jun Yao, Haojie Lu, Qiongzhu Dong, Haijun Zhou and Lunxiu Qin
    Citation: Proteome Science 2014 12:4
    Content type: Research Published on:
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